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Agmatine: clinical applications after 100 years in translation

Authors
 John E. Piletz  ;  Feyza Aricioglu  ;  Juei-Tang Cheng  ;  Carolyn A. Fairbanks  ;  Varda H. Gilad  ;  Britta Haenisch  ;  Angelos Halaris  ;  Samin Hong  ;  Jong Eun Lee  ;  Jin Li  ;  Ping Liu  ;  Gerhard J. Molderings  ;  Ana Lúcia S. Rodrigues  ;  Joseph Satriano  ;  Gong Je Seong  ;  George Wilcox  ;  Ning Wu  ;  Gad M. Gilad 
Citation
 DRUG DISCOVERY TODAY, Vol.18(17-18) : 880-893, 2013 
Journal Title
 DRUG DISCOVERY TODAY 
ISSN
 1359-6446 
Issue Date
2013
MeSH
Agmatine/chemistry ; Agmatine/history ; Agmatine/metabolism ; Agmatine/pharmacology ; Agmatine/therapeutic use* ; Animals ; Drug Discovery*/history ; History, 20th Century ; History, 21st Century ; Humans ; Signal Transduction/drug effects ; Tissue Distribution
Keywords
Agmatine/chemistry ; Agmatine/history ; Agmatine/metabolism ; Agmatine/pharmacology ; Agmatine/therapeutic use* ; Animals ; Drug Discovery*/history ; History, 20th Century ; History, 21st Century ; Humans ; Signal Transduction/drug effects ; Tissue Distribution
Abstract
Agmatine (decarboxylated arginine) has been known as a natural product for over 100 years, but its biosynthesis in humans was left unexplored owing to long-standing controversy. Only recently has the demonstration of agmatine biosynthesis in mammals revived research, indicating its exceptional modulatory action at multiple molecular targets, including neurotransmitter systems, nitric oxide (NO) synthesis and polyamine metabolism, thus providing bases for broad therapeutic applications. This timely review, a concerted effort by 16 independent research groups, draws attention to the substantial preclinical and initial clinical evidence, and highlights challenges and opportunities, for the use of agmatine in treating a spectrum of complex diseases with unmet therapeutic needs, including diabetes mellitus, neurotrauma and neurodegenerative diseases, opioid addiction, mood disorders, cognitive disorders and cancer.
Full Text
http://www.sciencedirect.com/science/article/pii/S1359644613001633
DOI
10.1016/j.drudis.2013.05.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
Hong, Sa Min(홍사민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87538
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