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Effects of mineral trioxide aggregate on the proliferation and differentiation of human dental pulp stromal cells from permanent and deciduous teeth
DC Field | Value | Language |
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dc.contributor.author | 김승혜 | - |
dc.contributor.author | 송제선 | - |
dc.contributor.author | 신동민 | - |
dc.contributor.author | 이제호 | - |
dc.contributor.author | 전미정 | - |
dc.date.accessioned | 2014-12-18T09:03:34Z | - |
dc.date.available | 2014-12-18T09:03:34Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1226-8496 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87455 | - |
dc.description.abstract | Mineral trioxide aggregate (MTA) has recently been used as a pulpotomy medicament for primary molars. The aim of this study was to evaluate and compare the proliferation and differentiation potential of dental pulp stromal cells of permanent teeth and deciduous teeth cultured on MTA-coated surface. Human dental pulp stromal cells were obtained from human permanent premolars and deciduous teeth and cultured on MTA-coated culture plates. The cells were subjected to proliferation assay and cell cycle analysis. Their differentiation potential was evaluated by analysing changes in the mRNA expressions of runt-related transcriptional factor 2 (Runx2) and alkaline phosphatase (ALP). Morphological changes of cells in direct contact with MTA were observed using scanning electron microscopy (SEM). The proliferation rates, distribution of cell cycles and mRNA expression patterns of Runx2 and ALP were similar in both types of pulpal cells. SEM observations revealed that both types changed into more dendrite-like cells. On the surface of MTA, human dental pulp stromal cells from deciduous and permanent teeth were able to both proliferate and differentiate into cells that induce mineralization. MTA is suitable as a biocompatible pulpotomy medicament for primary teeth. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | Journal of the Korean Academy of Pediatric Dentistry (대한소아치과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effects of mineral trioxide aggregate on the proliferation and differentiation of human dental pulp stromal cells from permanent and deciduous teeth | - |
dc.title.alternative | Mineral trioxide aggregate가 유치 및 영구치의 치수기질세포 증식 및 분화에 미치는 영향 | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Pediatric Dentistry (소아치과학) | - |
dc.contributor.googleauthor | Kim, Seunghye | - |
dc.contributor.googleauthor | Jeon, Mijeong | - |
dc.contributor.googleauthor | Shin, Dong Min | - |
dc.contributor.googleauthor | Lee, Jae Ho | - |
dc.contributor.googleauthor | Song, Je Seon | - |
dc.identifier.doi | 10.5933/JKAPD.2013.40.3.185 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02058 | - |
dc.contributor.localId | A02091 | - |
dc.contributor.localId | A03134 | - |
dc.contributor.localId | A03511 | - |
dc.contributor.localId | A00664 | - |
dc.relation.journalcode | J01802 | - |
dc.identifier.pmid | Mineral Trioxide Aggregate (MTA) ; Human dental pulp stromal cells ; Deciduous teeth ; Permanent teeth ; Proliferation ; Differentiation | - |
dc.subject.keyword | Mineral Trioxide Aggregate (MTA) | - |
dc.subject.keyword | Human dental pulp stromal cells | - |
dc.subject.keyword | Deciduous teeth | - |
dc.subject.keyword | Permanent teeth | - |
dc.subject.keyword | Proliferation | - |
dc.subject.keyword | Differentiation | - |
dc.contributor.alternativeName | Kim, Seung Hye | - |
dc.contributor.alternativeName | Song, Je Seon | - |
dc.contributor.alternativeName | Shin, Dong Min | - |
dc.contributor.alternativeName | Lee, Jae Ho | - |
dc.contributor.alternativeName | Jeon, Mi Jeong | - |
dc.contributor.affiliatedAuthor | Song, Je Seon | - |
dc.contributor.affiliatedAuthor | Shin, Dong Min | - |
dc.contributor.affiliatedAuthor | Lee, Jae Ho | - |
dc.contributor.affiliatedAuthor | Jeon, Mi Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Seung Hye | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 40 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 158 | - |
dc.citation.endPage | 166 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Academy of Pediatric Dentistry (대한소아치과학회지), Vol.40(3) : 158-166, 2013 | - |
dc.identifier.rimsid | 34237 | - |
dc.type.rims | ART | - |
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