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An Odorant-Binding Protein Required for Suppression of Sweet Taste by Bitter Chemicals

Authors
 Yong Taek Jeong  ;  Jaewon Shim  ;  So Ra Oh  ;  Hong In Yoon  ;  Chul Hoon Kim  ;  Seok Jun Moon  ;  Craig Montell 
Citation
 Neuron, Vol.79(4) : 725-737, 2013 
Journal Title
 Neuron 
ISSN
 0896-6273 
Issue Date
2013
Abstract
Animals often must decide whether or not to consume a diet that contains competing attractive and aversive compounds. Here, using the fruit fly, Drosophila melanogaster, we describe a mechanism that influences this decision. Addition of bitter compounds to sucrose suppressed feeding behavior, and this inhibition depended on an odorant-binding protein (OBP) termed OBP49a. In wild-type flies, bitter compounds suppressed sucrose-induced action potentials, and the inhibition was impaired in Obp49a mutants. However, loss of OBP49a did not affect action potentials in sugar- or bitter-activated gustatory receptor neurons (GRNs) when the GRNs were presented with just one type of tastant. OBP49a was expressed in accessory cells and acted non-cell-autonomously to attenuate nerve firings in sugar-activated GRNs when bitter compounds were combined with sucrose. These findings demonstrate an unexpected role for an OBP in taste and identify a molecular player involved in the integration of opposing attractive and aversive gustatory inputs.
Full Text
http://www.sciencedirect.com/science/article/pii/S0896627313005412
DOI
10.1016/j.neuron.2013.06.025
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
Shim, Jae Won(심재원)
Oh, So Ra(오소라)
Yoon, Hong In(윤홍인) ORCID logo https://orcid.org/0000-0002-2106-6856
Jeong, Yong Taek(정용택) ORCID logo https://orcid.org/0000-0003-0067-6396
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87347
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