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Stereotactic Body Radiotherapy with Helical Tomotherapy for Pain Palliation in Spine Metastasis

Authors
 M. S. Kim  ;  K. C. Keum  ;  J. H. Cha  ;  J. H. Kim  ;  J. S. Seong  ;  C. G. Lee  ;  K. C. Nam  ;  W. S. Koom 
Citation
 Technology in Cancer Research & Treatment, Vol.12(4) : 363-370, 2013 
Journal Title
 Technology in Cancer Research & Treatment 
ISSN
 1533-0346 
Issue Date
2013
MeSH
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Pain, Intractable/therapy* ; Palliative Care/methods* ; Radiosurgery/adverse effects ; Radiosurgery/methods* ; Radiotherapy, Intensity-Modulated/adverse effects ; Radiotherapy, Intensity-Modulated/methods* ; Spinal Neoplasms/mortality ; Spinal Neoplasms/secondary* ; Survival Rate
Keywords
Stereotactic body radiotherapy ; Helical tomotherapy ; Spine metastasis ; Pain palliation
Abstract
To evaluate the pain response, local tumor control and toxicity of stereotactic body radiotherapy (SBRT) with helical tomotherapy (HT) in the patients with spine metastasis. From May 2009 to June 2010, 22 patients with 31 lesions were treated by SBRT. Dose scheme were 24 Gy in 3 fractions (87.1%), 30 Gy in 5 fractions (9.7%), and 16 Gy in a single fraction (3.2%). Pain was assessed using a numerical rating scale. Analgesic consumption was recalculated into the daily oral morphine-equivalent dose (OMED). The response criteria of International Bone Metastases Consensus Group (IBMCG) was used. The median follow-up duration was 10 months (range 3-23 months). After SBRT the mean pain score decreased significantly (4.32 before SBRT, 0.71 at 3 months). However, median OMED didn't decrease until 3 months after SBRT (Median OMED; 34.5 mg before SBRT, 45 mg at 3 months). Pain response rate and pain progression-free survival rate at 3 month was 96.8 and 93.5%, respectively. Local progression-free survival rate at 3 month was 93.5%. There was no severe acute toxicity. SBRT with HT is a safe and effective treatment modality for local tumor control and pain palliation associated with spine metastasis.
Full Text
http://www.tcrt.org/product-p18032.html
DOI
10.7785/tcrt.2012.500329
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Koom, Woong Sub(금웅섭) ORCID logo https://orcid.org/0000-0002-9435-7750
Kim, Ji Hong(김지홍)
Nam, Ki Chang(남기창)
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Lee, Chang Geol(이창걸) ORCID logo https://orcid.org/0000-0002-8702-881X
Cha, Ji Hye(차지혜)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87180
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