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“Chemical-pain sensor” based on nanovesicle-carbon nanotube hybrid structures

Authors
 Hye Jun Jin  ;  Jeong Mi An  ;  Juhun Park  ;  Seok Jun Moon  ;  Seunghun Hong 
Citation
 BIOSENSORS & BIOELECTRONICS, Vol.49 : 86-91, 2013 
Journal Title
 BIOSENSORS & BIOELECTRONICS 
ISSN
 0956-5663 
Issue Date
2013
MeSH
Animals ; Biosensing Techniques/instrumentation* ; Capsaicin/adverse effects ; Cloning, Molecular ; Diterpenes/adverse effects ; HEK293 Cells ; Hot Temperature ; Humans ; Immobilized Proteins/chemistry ; Immobilized Proteins/genetics ; Immobilized Proteins/metabolism* ; Limit of Detection ; Nanostructures/chemistry ; Nanotubes, Carbon/chemistry* ; Pain/chemically induced* ; Pain/metabolism ; Rats ; Sensitivity and Specificity ; Sensory System Agents/adverse effects ; TRPV Cation Channels/chemistry ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism*
Keywords
Carbon nanotube ; Field effect transistor ; Hybrid structure ; Nanovesicle ; Pain sensor
Abstract
We developed a "chemical-pain sensor" that could recognize chemical pain stimuli such as capsaicin and resiniferatoxin just like mammalian chemical pain sensory systems. Here, we first prepared nanovesicles containing rat pain sensory receptor, rat transient receptor potential vanilloid 1 (rTRPV1), which is activated by noxious heat and capsaicin. And the nanovesicles were immobilized on a single-walled carbon nanotube-based field effect transistor. The chemical-pain sensor could selectively detect chemical pain stimuli with a high sensitivity of a 1 pM detection limit. It also responded to different chemical pain stimuli in a manner similar as to that of mammalian chemical pain sensory systems. This sensor platform can be utilized for various practical applications such as food screening tools and artificial somesthetic sensors. Moreover, TRP families have been suggested as potential drug targets related to nerve and circulation disorders. Thus, the capability of monitoring TRP responses using our sensor platforms should provide a powerful means for the development of new drugs as well as the basic research about nerve and circulation systems.
Full Text
http://www.sciencedirect.com/science/article/pii/S0956566313003114
DOI
10.1016/j.bios.2013.04.045
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
An, Jeong Mi(안정미)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87025
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