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“Chemical-pain sensor” based on nanovesicle-carbon nanotube hybrid structures

DC FieldValueLanguage
dc.contributor.author문석준-
dc.contributor.author안정미-
dc.date.accessioned2014-12-18T08:49:42Z-
dc.date.available2014-12-18T08:49:42Z-
dc.date.issued2013-
dc.identifier.issn0956-5663-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87025-
dc.description.abstractWe developed a "chemical-pain sensor" that could recognize chemical pain stimuli such as capsaicin and resiniferatoxin just like mammalian chemical pain sensory systems. Here, we first prepared nanovesicles containing rat pain sensory receptor, rat transient receptor potential vanilloid 1 (rTRPV1), which is activated by noxious heat and capsaicin. And the nanovesicles were immobilized on a single-walled carbon nanotube-based field effect transistor. The chemical-pain sensor could selectively detect chemical pain stimuli with a high sensitivity of a 1 pM detection limit. It also responded to different chemical pain stimuli in a manner similar as to that of mammalian chemical pain sensory systems. This sensor platform can be utilized for various practical applications such as food screening tools and artificial somesthetic sensors. Moreover, TRP families have been suggested as potential drug targets related to nerve and circulation disorders. Thus, the capability of monitoring TRP responses using our sensor platforms should provide a powerful means for the development of new drugs as well as the basic research about nerve and circulation systems.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfBIOSENSORS & BIOELECTRONICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBiosensing Techniques/instrumentation*-
dc.subject.MESHCapsaicin/adverse effects-
dc.subject.MESHCloning, Molecular-
dc.subject.MESHDiterpenes/adverse effects-
dc.subject.MESHHEK293 Cells-
dc.subject.MESHHot Temperature-
dc.subject.MESHHumans-
dc.subject.MESHImmobilized Proteins/chemistry-
dc.subject.MESHImmobilized Proteins/genetics-
dc.subject.MESHImmobilized Proteins/metabolism*-
dc.subject.MESHLimit of Detection-
dc.subject.MESHNanostructures/chemistry-
dc.subject.MESHNanotubes, Carbon/chemistry*-
dc.subject.MESHPain/chemically induced*-
dc.subject.MESHPain/metabolism-
dc.subject.MESHRats-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSensory System Agents/adverse effects-
dc.subject.MESHTRPV Cation Channels/chemistry-
dc.subject.MESHTRPV Cation Channels/genetics-
dc.subject.MESHTRPV Cation Channels/metabolism*-
dc.title“Chemical-pain sensor” based on nanovesicle-carbon nanotube hybrid structures-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorHye Jun Jin-
dc.contributor.googleauthorJeong Mi An-
dc.contributor.googleauthorJuhun Park-
dc.contributor.googleauthorSeok Jun Moon-
dc.contributor.googleauthorSeunghun Hong-
dc.identifier.doi10.1016/j.bios.2013.04.045-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01358-
dc.contributor.localIdA02257-
dc.relation.journalcodeJ00330-
dc.identifier.eissn1873-4235-
dc.identifier.pmid23722046-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0956566313003114-
dc.subject.keywordCarbon nanotube-
dc.subject.keywordField effect transistor-
dc.subject.keywordHybrid structure-
dc.subject.keywordNanovesicle-
dc.subject.keywordPain sensor-
dc.contributor.alternativeNameMoon, Seok Jun-
dc.contributor.alternativeNameAn, Jeong Mi-
dc.contributor.affiliatedAuthorMoon, Seok Jun-
dc.contributor.affiliatedAuthorAn, Jeong Mi-
dc.rights.accessRightsnot free-
dc.citation.volume49-
dc.citation.startPage86-
dc.citation.endPage91-
dc.identifier.bibliographicCitationBIOSENSORS & BIOELECTRONICS, Vol.49 : 86-91, 2013-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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