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Tuberculin Skin Test and Boosted Reactions among Newly Employed Healthcare Workers: An Observational Study

Authors
 Song Yee Kim  ;  Moo Suk Park  ;  Young Sam Kim  ;  Se Kyu Kim  ;  Joon Chang  ;  Dong eun Yong  ;  Hyun Sook Kim  ;  Kyungwon Lee  ;  Young Ae Kang 
Citation
 PLOS ONE, Vol.8(5) : e64563, 2013 
Journal Title
 PLOS ONE 
Issue Date
2013
MeSH
Adult ; Aged ; Female ; Follow-Up Studies ; Health Personnel* ; Humans ; Latent Tuberculosis/diagnosis* ; Latent Tuberculosis/epidemiology ; Male ; Middle Aged ; Prevalence ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; Tuberculin Test* ; Young Adult
Keywords
Adult ; Aged ; Female ; Follow-Up Studies ; Health Personnel* ; Humans ; Latent Tuberculosis/diagnosis* ; Latent Tuberculosis/epidemiology ; Male ; Middle Aged ; Prevalence ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; Tuberculin Test* ; Young Adult
Abstract
OBJECTIVE: To evaluate the prevalence of and factors associated with latent tuberculosis infection (LTBI) based on the tuberculin skin test (TST) and to estimate the boosted reaction rate among newly employed healthcare workers (HCWs). DESIGN: Newly employed HCWs between January 2010 and July 2012 at Severance Hospital in South Korea were enrolled in this study. A one-step TST was conducted before October 2011, and a two-step TST after October 2011. RESULTS: Of 2132 participants, 778 (36.5%) had positive TST results. Being older (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.06-1.13, P<0.001), male (OR 1.78, 95% CI 1.21-2.62, P = 0.003), rejoining the hospital workforce (OR 1.58, 95% CI 1.04-2.40, P = 0.032), and having a previous history of tuberculosis (TB) (OR 18.21, 95% CI 2.15-154.10, P = 0.008) during the one-step period, and being older (OR 1.15, 95% CI 1.10-1.21, P<0.001) during the two-step period were significantly associated with a positive TST. A two-step TST was performed in 556 HCWs, and a boosted reaction was observed in 79 (14.2%). The induration size on the first TST (5-9-mm group) was the only factor associated with a boosted reaction on the second TST. CONCLUSIONS: The prevalence of LTBI based on the TST among newly employed HCWs was high. The boosted reaction rate on two-step TST was not low; therefore, the use of two-step TST may be necessary for regular monitoring in countries with an intermediate TB burden and a high rate of Bacillus Calmette-Guérin vaccination.
Files in This Item:
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DOI
10.1371/journal.pone.0064563
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Se Kyu(김세규)
Kim, Song Yee(김송이) ORCID logo https://orcid.org/0000-0001-8627-486X
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87019
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