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Pleiotropic Functions of Fibroblast Growth Factor Signaling in Embryonic Mammary Gland Development

Authors
 Eun-Jung Kim  ;  Han-Sung Jung  ;  Pengfei Lu 
Citation
 JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, Vol.18(2) : 139-142, 2013 
Journal Title
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
ISSN
 1083-3021 
Issue Date
2013
MeSH
Animals ; Female ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism* ; Gene Expression Regulation, Developmental ; Humans ; Mammary Glands, Animal/embryology* ; Mammary Glands, Animal/metabolism ; Mammary Glands, Human/embryology* ; Mammary Glands, Human/metabolism ; Signal Transduction
Keywords
Mammary placode ; Epithelial-mesenchymal interactions ; FGF signaling ; Vertebrate organogenesis
Abstract
The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted for induction, maintenance and morphogenesis of the mammary glands. Understanding the mechanism whereby FGF signaling regulates the fundamental cell behavior during normal mammary gland develop may facilitate determination of the consequences of its deregulation during breast cancer progression.
Full Text
http://link.springer.com/article/10.1007%2Fs10911-013-9278-4
DOI
10.1007/s10911-013-9278-4
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eun-Jung(김은정) ORCID logo https://orcid.org/0000-0002-9515-7590
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87002
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