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MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKIIδ

Authors
 Min-Ji Cha  ;  Jin-Kyung Jang  ;  Onju Ham  ;  Byeong-Wook Song  ;  Se-Yeon Lee  ;  Chang Yeon Lee  ;  Jun-Hee Park  ;  Jiyun Lee  ;  Hyang-Hee Seo  ;  Eunhyun Choi  ;  Woo-min Jeon  ;  Hye Jin Hwang  ;  Hyun-Taek Shin  ;  Eunmi Choi  ;  Ki-Chul Hwang 
Citation
 Biochemical and Biophysical Research Communications, Vol.435(4) : 720-726, 2013 
Journal Title
 Biochemical and Biophysical Research Communications 
ISSN
 0006-291X 
Issue Date
2013
Abstract
A change in intracellular free calcium (Ca(2+)) is a common signaling mechanism of reperfusion-induced cardiomyocyte death. Calcium/calmodulin dependent protein kinase II (CaMKII) is a critical regulator of Ca(2+) signaling and mediates signaling pathways responsible for functions in the heart including hypertrophy, apoptosis, arrhythmia, and heart disease. MicroRNAs (miRNA) are involved in the regulation of cell response, including survival, proliferation, apoptosis, and development. However, the roles of miRNAs in Ca(2+)-mediated apoptosis of cardiomyocytes are uncertain. Here, we determined the potential role of miRNA in the regulation of CaMKII dependent apoptosis and explored its underlying mechanism. To determine the potential roles of miRNAs in H2O2-mediated Ca(2+) overload, we selected and tested 6 putative miRNAs that targeted CaMKIIδ, and showed that miR-145 represses CaMKIIδ protein expression and Ca(2+) overload. We confirmed CaMKIIδ as a direct downstream target of miR-145. Furthermore, miR-145 regulates Ca(2+)-related signals and ameliorates apoptosis. This study demonstrates that miR-145 regulates reactive oxygen species (ROS)-induced Ca(2+) overload in cardiomyocytes. Thus, miR-145 affects ROS-mediated gene regulation and cellular injury responses.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86902
DOI
10.1016/j.bbrc.2013.05.050
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
Yonsei Authors
박준희(Park, Jun-Hee)
서향희(Seo, Hyang Hee)
송병욱(Song, Byeong Wook)
이세연(Lee, Se Yeon)
이지윤(Lee, Ji Yun)
이창연(Lee, Chang Yeon)
차민지(Cha, Min Ji)
최은미(Choi, Eun Mi)
최은현(Choi, Eun Hyun)
함온주(Ham, On Ju)
황기철(Hwang, Ki Chul)
황혜진(Hwang, Hye Jin)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X13008334
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