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Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects

Authors
 Chan Joo Lee  ;  Yong-ho Lee  ;  Sahng Wook Park  ;  Kwang Joon Kim  ;  Sungha Park  ;  Jong-Chan Youn  ;  Sang-Hak Lee  ;  Seok-Min Kang  ;  Yangsoo Jang 
Citation
 Metabolism: Clinical and Experimental, Vol.62(6) : 845-850, 2013 
Journal Title
 Metabolism: Clinical and Experimental 
ISSN
 0026-0495 
Issue Date
2013
MeSH
Aged ; Atherosclerosis/etiology ; Atherosclerosis/physiopathology* ; Carotid Intima-Media Thickness* ; Disease Susceptibility ; Female ; Humans ; Hypertension/physiopathology* ; Male ; Middle Aged ; Proprotein Convertase 9 ; Proprotein Convertases/blood* ; Serine Endopeptidases/blood*
Keywords
PCSK9 ; Atherosclerosis ; Carotid IMT (Intima–media thickness)
Abstract
OBJECTIVE: The clinical significance of the measurement of serum PCSK9 (proprotein subtilisin kexin type 9) is not well defined. This study investigated the association between serum PCSK9 levels and atherosclerosis assessed by carotid intima media thickness (IMT) in hypertensive patients. METHODS: A total of 126 hypertensive patients over the age of 45 were enrolled. The maximum carotid IMT (max-IMT) and the mean carotid IMT (mean-IMT) were measured at the time of enrollment. Clinical and laboratory parameters including serum PCSK9 were analyzed. RESULTS: Patients were divided into tertiles based on serum PCSK9 levels. After adjusting for age, sex, total cholesterol, HDL-cholesterol and triglyceride, max-IMT was significantly increased in the highest tertile of serum PCSK9 (0.969±0.033 vs 0.959±0.033 vs 1.077±0.033 mm, respectively; P=0.026). Mean-IMT showed a tendency to increase across the tertile groups (0.773±0.025 vs 0.790±0.026 vs 0.856±0.025 mm, respectively; P=0.059). Multivariate regression analysis revealed that serum PCSK9 was independently associated with carotid IMT (max-IMT: β=0.212, P=0.016; mean-IMT: β=0.184, P=0.04). CONCLUSION: The present study is the first to report the association between serum PCSK9 levels and carotid IMT in hypertensive patients. These results suggest that serum PCSK9 may have a certain role in early pathogenesis of atherosclerosis.
Full Text
http://www.sciencedirect.com/science/article/pii/S0026049513000061
DOI
10.1016/j.metabol.2013.01.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
7. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Park, Sahng Wook(박상욱) ORCID logo https://orcid.org/0000-0002-9594-7074
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Youn, Jong Chan(윤종찬)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Lee, Chan Joo(이찬주) ORCID logo https://orcid.org/0000-0002-8756-409X
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86822
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