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Incidence of and risk factors for active tuberculosis in human immunodeficiency virus-infected patients in South Korea

Authors
 Ku, N. S.  ;  Choi, Y. H.  ;  Kim, Y. K.  ;  Choi, J. P.  ;  Kim, J. M.  ;  Choi, J. Y. 
Citation
 INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol.17(6) : 777-781, 2013 
Journal Title
 INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 
ISSN
 1027-3719 
Issue Date
2013
MeSH
Adult ; Body Mass Index ; CD4 Lymphocyte Count ; Case-Control Studies ; Female ; Follow-Up Studies ; HIV Infections/epidemiology* ; Humans ; Incidence ; Male ; Middle Aged ; Multivariate Analysis ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; Smoking/adverse effects ; Smoking/epidemiology* ; Tuberculosis/epidemiology* ; Tuberculosis/etiology
Keywords
HIV ; TB ; incidence ; risk factors
Abstract
BACKGROUND: In South Korea, a high-income country with an intermediate tuberculosis (TB) burden and low human immunodeficiency virus (HIV) prevalence, studies on incidence and risk factors of TB in HIV-infected persons have rarely been reported. OBJECTIVE: To investigate the incidence of and risk factors for active TB in HIV-infected persons in South Korea. METHODS: A retrospective analysis was conducted of 1265 HIV-1 infected patients who visited four hospitals in South Korea between 1985 and 2012. We analysed the incidence of TB during the follow-up period. To investigate risk factors associated with active TB, we conducted a 1:2 matched case-control study of HIV-infected patients with newly active TB and controls without active TB who had similar CD4(+) T-cell counts and dates of first visit. RESULTS: Over a total of 4457 person-years (py), 185 (14.6%) subjects were diagnosed with active TB; the incidence was 4.2 cases/100 py. In multivariate analysis, low body mass index (P = 0.033) and current smoking (P = 0.003) were independent risk factors for TB in HIV-infected patients. CONCLUSION: Further strategies on prevention and treatment of active TB among HIV-infected patients should be implemented in South Korea. Encouraging smoking cessation and supporting good nutrition may be ways to reduce the incidence of active TB in HIV-infected patients.
Full Text
http://www.ingentaconnect.com/content/iuatld/ijtld/2013/00000017/00000006/art00013?token=00511fd003c38e7ec150ade67232d45232b45246c7b6f2c6b667323663568293c62207d673f582f6b
DOI
10.5588/ijtld.12.0607
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, June Myung(김준명)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86816
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