Cited 35 times in
Hyaluronic acid receptor-targetable imidazolized nanovectors for induction of gastric cancer cell death by RNA interference
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 임은경 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2014-12-18T08:42:41Z | - |
dc.date.available | 2014-12-18T08:42:41Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86812 | - |
dc.description.abstract | We have developed a nanovector consisting of hyaluronic acid (HA) and poly-l-lysine-graft-imidazole (PLI)-based polyplexes containing Bcl-xL-specific shRNA-encoding plasmid DNA (HA/PLI/pDNA) for CD44 targeted gastric cancer therapy. The prepared ternary polyplexes have a negative surface charge of −24 mV and a size of approximately 100 nm at an N/P ratio of 5 with HA/PLI molar ratio of 0.03. Gel electrophoresis and cell viability experiments demonstrated that the ternary polyplexes showed high stability and no cytotoxicity due to the anchored HA molecules on the surface of PLI/pDNA binary polyplexes. Selective cancer cell death was achieved by CD44-mediated gene delivery and the internalized gene was effectively escaped from endosomes due to the buffering capacity of imidazole groups in an acidic environment. These nanovectors may be highly efficient gene delivery tools that allow the selective destruction of metastatic gastric cancer cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Death/drug effects | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | DNA/metabolism | - |
dc.subject.MESH | Electrophoretic Mobility Shift Assay | - |
dc.subject.MESH | Genetic Vectors/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyaluronan Receptors/metabolism* | - |
dc.subject.MESH | Hydrogen-Ion Concentration | - |
dc.subject.MESH | Imidazoles/chemistry* | - |
dc.subject.MESH | Intracellular Space/metabolism | - |
dc.subject.MESH | Magnetic Resonance Spectroscopy | - |
dc.subject.MESH | Nanoparticles/chemistry* | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Plasmids/metabolism | - |
dc.subject.MESH | Polylysine/chemistry | - |
dc.subject.MESH | RNA Interference* | - |
dc.subject.MESH | RNA, Small Interfering/metabolism | - |
dc.subject.MESH | Static Electricity | - |
dc.subject.MESH | Stomach Neoplasms/pathology* | - |
dc.subject.MESH | Transfection | - |
dc.subject.MESH | bcl-X Protein/metabolism | - |
dc.title | Hyaluronic acid receptor-targetable imidazolized nanovectors for induction of gastric cancer cell death by RNA interference | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute for Medical Convergence (연의-생공연 메디컬융합연구소) | - |
dc.contributor.googleauthor | Eunjung Kim | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Hyun-Ouk Kim | - |
dc.contributor.googleauthor | Yonghee An | - |
dc.contributor.googleauthor | Eun-Kyung Lim | - |
dc.contributor.googleauthor | Gyudo Lee | - |
dc.contributor.googleauthor | Taeyun Kwon | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1016/j.biomaterials.2013.02.006 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A03391 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A02315 | - |
dc.relation.journalcode | J00312 | - |
dc.identifier.eissn | 1878-5905 | - |
dc.identifier.pmid | 23478035 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0142961213001750 | - |
dc.subject.keyword | Hyaluronic acid | - |
dc.subject.keyword | Imidazole | - |
dc.subject.keyword | Buffering | - |
dc.subject.keyword | RNA interference | - |
dc.subject.keyword | Gene delivery | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Lim, Eun Kyung | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Lim, Eun Kyung | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 4327 | - |
dc.citation.endPage | 4338 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, Vol.34(17) : 4327-4338, 2013 | - |
dc.identifier.rimsid | 29219 | - |
dc.type.rims | ART | - |
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