3 292

Cited 22 times in

The association between chemerin and homeostasis assessment of insulin resistance at baseline and after weight reduction via lifestyle modifications in young obese adults

 Mi Kyung Lee  ;  Sang Hui Chu  ;  Duk Chul Lee  ;  Ki Yong An  ;  Ji-Hye Park  ;  Dong Il Kim  ;  Jiyoung Kim  ;  Sunghyun Hong  ;  Jee Aee Im  ;  Ji Won Lee  ;  Justin Y. Jeon 
 CLINICA CHIMICA ACTA, Vol.421 : 109-115, 2013 
Journal Title
Issue Date
Adiponectin/blood ; Adult ; Body Mass Index ; C-Reactive Protein/analysis ; Chemokines/blood* ; Exercise ; Fasting ; Female ; Homeostasis ; Humans ; Insulin/blood* ; Insulin Resistance* ; Intercellular Signaling Peptides and Proteins ; Intra-Abdominal Fat/metabolism ; Intra-Abdominal Fat/pathology ; Life Style ; Male ; Obesity/blood* ; Obesity/pathology ; Subcutaneous Fat/metabolism ; Subcutaneous Fat/pathology ; Weight Loss*
Chemerin ; Obesity ; Insulin resistance ; Lifestyle modification ; Exercise
BACKGROUND: Chemerin is a recently discovered adipocytokine, associated with adiposity and insulin sensitivity. The current study investigated the effects of lifestyle intervention on circulating chemerin level and its association with insulin resistance and adiponectin in human. METHODS: Forty male and 20 female obese adults (mean age: 29.7±5.7 y, mean BMI: 29.3±4.5 kg/m(2)) completed an 8-week lifestyle intervention program, which consisted of a home-based diet and exercise program. Anthropometric measurements and biomarkers were assessed at the baseline and at the end of the study. RESULTS: Eight weeks of lifestyle intervention reduced body weight, visceral fat and subcutaneous fat by 3.8%, 15.3% and 11.5%, respectively. The lifestyle intervention further reduced fasting insulin (10.9±6.6 vs. 7.6±5.3 μU/ml, p<0.001) and homeostasis assessment of insulin resistance (HOMA-IR) (2.3±1.5 vs. 1.6±1.2, p<0.001), chemerin (103.3±20.7 vs. 96.5±19.5 ng/ml, p<0.001) and hs-CRP levels (1.3±1.8 vs. 0.2±0.2 mg/dl, p<0.001) while it increased fasting pentraxin (PTX) 3 (0.6±0.7 vs. 0.7±0.4 ng/ml, p=0.049) level. The Δ chemerin levels correlated with Δ insulin (r=0.349, p=0.024) and HOMA-IR (r=0.333, p=0.36) even after adjusting for age and gender. CONCLUSION: The lifestyle intervention reduced circulating chemerin levels independent of visceral fat mass and adiponectin. Chemerin levels are associated with insulin resistance at the baseline and after the lifestyle intervention.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
Chu, Sang Hui(추상희) ORCID logo https://orcid.org/0000-0001-6877-5599
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.