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The association between chemerin and homeostasis assessment of insulin resistance at baseline and after weight reduction via lifestyle modifications in young obese adults

DC FieldValueLanguage
dc.contributor.author이덕철-
dc.contributor.author이지원-
dc.contributor.author추상희-
dc.date.accessioned2014-12-18T08:34:58Z-
dc.date.available2014-12-18T08:34:58Z-
dc.date.issued2013-
dc.identifier.issn0009-8981-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86576-
dc.description.abstractBACKGROUND: Chemerin is a recently discovered adipocytokine, associated with adiposity and insulin sensitivity. The current study investigated the effects of lifestyle intervention on circulating chemerin level and its association with insulin resistance and adiponectin in human. METHODS: Forty male and 20 female obese adults (mean age: 29.7±5.7 y, mean BMI: 29.3±4.5 kg/m(2)) completed an 8-week lifestyle intervention program, which consisted of a home-based diet and exercise program. Anthropometric measurements and biomarkers were assessed at the baseline and at the end of the study. RESULTS: Eight weeks of lifestyle intervention reduced body weight, visceral fat and subcutaneous fat by 3.8%, 15.3% and 11.5%, respectively. The lifestyle intervention further reduced fasting insulin (10.9±6.6 vs. 7.6±5.3 μU/ml, p<0.001) and homeostasis assessment of insulin resistance (HOMA-IR) (2.3±1.5 vs. 1.6±1.2, p<0.001), chemerin (103.3±20.7 vs. 96.5±19.5 ng/ml, p<0.001) and hs-CRP levels (1.3±1.8 vs. 0.2±0.2 mg/dl, p<0.001) while it increased fasting pentraxin (PTX) 3 (0.6±0.7 vs. 0.7±0.4 ng/ml, p=0.049) level. The Δ chemerin levels correlated with Δ insulin (r=0.349, p=0.024) and HOMA-IR (r=0.333, p=0.36) even after adjusting for age and gender. CONCLUSION: The lifestyle intervention reduced circulating chemerin levels independent of visceral fat mass and adiponectin. Chemerin levels are associated with insulin resistance at the baseline and after the lifestyle intervention.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCLINICA CHIMICA ACTA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdiponectin/blood-
dc.subject.MESHAdult-
dc.subject.MESHBody Mass Index-
dc.subject.MESHC-Reactive Protein/analysis-
dc.subject.MESHChemokines/blood*-
dc.subject.MESHExercise-
dc.subject.MESHFasting-
dc.subject.MESHFemale-
dc.subject.MESHHomeostasis-
dc.subject.MESHHumans-
dc.subject.MESHInsulin/blood*-
dc.subject.MESHInsulin Resistance*-
dc.subject.MESHIntercellular Signaling Peptides and Proteins-
dc.subject.MESHIntra-Abdominal Fat/metabolism-
dc.subject.MESHIntra-Abdominal Fat/pathology-
dc.subject.MESHLife Style-
dc.subject.MESHMale-
dc.subject.MESHObesity/blood*-
dc.subject.MESHObesity/pathology-
dc.subject.MESHSubcutaneous Fat/metabolism-
dc.subject.MESHSubcutaneous Fat/pathology-
dc.subject.MESHWeight Loss*-
dc.titleThe association between chemerin and homeostasis assessment of insulin resistance at baseline and after weight reduction via lifestyle modifications in young obese adults-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학)-
dc.contributor.googleauthorMi Kyung Lee-
dc.contributor.googleauthorSang Hui Chu-
dc.contributor.googleauthorDuk Chul Lee-
dc.contributor.googleauthorKi Yong An-
dc.contributor.googleauthorJi-Hye Park-
dc.contributor.googleauthorDong Il Kim-
dc.contributor.googleauthorJiyoung Kim-
dc.contributor.googleauthorSunghyun Hong-
dc.contributor.googleauthorJee Aee Im-
dc.contributor.googleauthorJi Won Lee-
dc.contributor.googleauthorJustin Y. Jeon-
dc.identifier.doi10.1016/j.cca.2013.02.017-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02716-
dc.contributor.localIdA04232-
dc.contributor.localIdA03203-
dc.relation.journalcodeJ00543-
dc.identifier.eissn1873-3492-
dc.identifier.pmid23485648-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0009898113000703-
dc.subject.keywordChemerin-
dc.subject.keywordObesity-
dc.subject.keywordInsulin resistance-
dc.subject.keywordLifestyle modification-
dc.subject.keywordExercise-
dc.contributor.alternativeNameLee, Duk Chul-
dc.contributor.alternativeNameLee, Ji Won-
dc.contributor.alternativeNameChoo, Sang Hee-
dc.contributor.affiliatedAuthorLee, Duk Chul-
dc.contributor.affiliatedAuthorChoo, Sang Hee-
dc.contributor.affiliatedAuthorLee, Ji Won-
dc.rights.accessRightsnot free-
dc.citation.volume421-
dc.citation.startPage109-
dc.citation.endPage115-
dc.identifier.bibliographicCitationCLINICA CHIMICA ACTA, Vol.421 : 109-115, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers

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