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Sonographic Characteristics Suggesting Papillary Thyroid Carcinoma According to Nodule Size

 Ga Ram Kim  ;  Myung Hyun Kim  ;  Hee Jung Moon  ;  Woong Youn Chung  ;  Jin Young Kwak  ;  Eun-Kyung Kim 
 Annals of Surgical Oncology, Vol.20(3) : 906-913, 2013 
Journal Title
 Annals of Surgical Oncology 
Issue Date
Purpose To determine differences in ultrasonography (US) features suggesting papillary thyroid carcinoma (PTC) between nodules larger than 10 mm (large lesions) and nodules ≤10 mm in diameter (small lesions). Methods We included 1,238 nodules in 1,173 patients that were confirmed through cytology or histopathology between February 2007 and June 2007 in the study. Nodules were divided into large lesions (571 lesions) and small lesions (667 lesions). Sonographic features were defined as composition, echogenicity, margin, calcifications, shape, and vascularity. Logistic regression analyses were performed to determine the odds ratios (OR) of each feature to predict PTC. Results On multivariate analysis, irregular margin (OR = 37.788, P < 0.001), microcalcifications (OR = 17.799, P < 0.001), microlobulated margin (OR = 10.385, P < 0.001), and no vascularity (OR = 5.975, P < 0.001) were independent factors for PTC in the large lesions and irregular margin (OR = 7.185, P < 0.001), microlobulated margin (OR = 5.952, P < 0.001), microcalcifications (OR = 3.722, P < 0.001), marked hypoechogenicity (OR = 2.873, P = 0.004), and taller than wide shape (OR = 2.698, P < 0.001) were independent factors for PTC in the small lesions. Conclusions The OR of each US finding for predicting PTC is different between large and small lesions. Therefore, it would be helpful to weight certain US features according to nodule size when reporting thyroid nodules with different risks of PTC.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
곽진영(Kwak, Jin Young) ORCID logo https://orcid.org/0000-0002-6212-1495
김가람(Kim, Ga Ram)
김명현(Kim, Myung Hyun)
김은경(Kim, Eun-Kyung) ORCID logo https://orcid.org/0000-0002-3368-5013
문희정(Moon, Hee Jung) ORCID logo https://orcid.org/0000-0002-5643-5885
정웅윤(Chung, Woung Youn)
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