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Sonographic Characteristics Suggesting Papillary Thyroid Carcinoma According to Nodule Size

Authors
 Ga Ram Kim  ;  Myung Hyun Kim  ;  Hee Jung Moon  ;  Woong Youn Chung  ;  Jin Young Kwak  ;  Eun-Kyung Kim 
Citation
 ANNALS OF SURGICAL ONCOLOGY, Vol.20(3) : 906-913, 2013 
Journal Title
 ANNALS OF SURGICAL ONCOLOGY 
ISSN
 1068-9265 
Issue Date
2013
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Calcinosis ; Carcinoma, Papillary/diagnostic imaging* ; Carcinoma, Papillary/pathology ; Child ; Cytodiagnosis* ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Thyroid Neoplasms/diagnostic imaging* ; Thyroid Neoplasms/pathology ; Thyroid Nodule/diagnostic imaging* ; Thyroid Nodule/pathology ; Ultrasonography ; Young Adult
Keywords
Papillary Thyroid Carcinoma ; Thyroid Nodule ; Small Lesion ; Large Lesion ; Nodule Size
Abstract
Purpose To determine differences in ultrasonography (US) features suggesting papillary thyroid carcinoma (PTC) between nodules larger than 10 mm (large lesions) and nodules ≤10 mm in diameter (small lesions). Methods We included 1,238 nodules in 1,173 patients that were confirmed through cytology or histopathology between February 2007 and June 2007 in the study. Nodules were divided into large lesions (571 lesions) and small lesions (667 lesions). Sonographic features were defined as composition, echogenicity, margin, calcifications, shape, and vascularity. Logistic regression analyses were performed to determine the odds ratios (OR) of each feature to predict PTC. Results On multivariate analysis, irregular margin (OR = 37.788, P < 0.001), microcalcifications (OR = 17.799, P < 0.001), microlobulated margin (OR = 10.385, P < 0.001), and no vascularity (OR = 5.975, P < 0.001) were independent factors for PTC in the large lesions and irregular margin (OR = 7.185, P < 0.001), microlobulated margin (OR = 5.952, P < 0.001), microcalcifications (OR = 3.722, P < 0.001), marked hypoechogenicity (OR = 2.873, P = 0.004), and taller than wide shape (OR = 2.698, P < 0.001) were independent factors for PTC in the small lesions. Conclusions The OR of each US finding for predicting PTC is different between large and small lesions. Therefore, it would be helpful to weight certain US features according to nodule size when reporting thyroid nodules with different risks of PTC.
Full Text
http://link.springer.com/article/10.1245/s10434-012-2830-4
DOI
10.1245/s10434-012-2830-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Ga Ram(김가람) ORCID logo https://orcid.org/0000-0002-4481-5792
Kim, Myung Hyun(김명현) ORCID logo https://orcid.org/0000-0002-5139-0155
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Chung, Woong Youn(정웅윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86549
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