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Local increase in microparticles from the aspirate of culprit coronary arteries in patients with ST-segment elevation myocardial infarction

Authors
 Pil-Ki Min  ;  Jong-Youn Kim  ;  Kwang-Hoe Chung  ;  Byoung Kwon Lee  ;  Minhee Cho  ;  Da-Lyung Lee  ;  Sung-Yu Hong  ;  Eui-Young Choi  ;  Young-Won Yoon  ;  Bum-Kee Hong  ;  Se-Joong Rim  ;  Hyuck Moon Kwon 
Citation
 Atherosclerosis, Vol.227(2) : 323-328, 2013 
Journal Title
 Atherosclerosis 
ISSN
 0021-9150 
Issue Date
2013
Abstract
OBJECTIVE: It has been reported that the levels of procoagulant microparticles (MPs) are increased in patients with acute coronary syndromes and this may contribute to the formation of intracoronary thrombi. In the current study, we investigated the presence of locally elevated MPs within the culprit coronary arteries of patients with ST-segment elevation myocardial infarction (STEMI). METHODS: The study population consisted of 45 patients with STEMI who underwent primary percutaneous coronary intervention (PCI), and 16 control patients. Before and after PCI, blood samples were collected from the femoral artery and from the culprit coronary arteries. In controls, only peripheral blood was obtained. MPs were measured by a solid-phase capture assay using a commercial kit. The cell origins of MPs were determined by antigenic capture with specific antibodies. RESULTS: Baseline levels of MPs in patients with STEMI were higher than in controls. Before PCI, the levels of MPs were significantly higher in culprit coronary arteries than in peripheral arteries in STEMI patients (20.7 ± 15.5 vs. 14.6 ± 15.4 nM phosphatidylserine (PS) equivalent, p = 0.027). MPs from the culprit coronary artery were significantly reduced after PCI (20.7 ± 15.5 vs. 14.3 ± 14.9 nM PS equivalent, p = 0.010). Similarly, the locally increased levels of endothelial- and platelet-derived MPs within the culprit coronary arteries were significantly decreased after PCI. CONCLUSION: Locally increased levels of MPs in culprit coronary arteries and their significant reduction after successful PCI suggest a potential role in coronary atherothrombosis in the early period of STEMI.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86476
Full Text
http://www.sciencedirect.com/science/article/pii/S0021915013000944
DOI
10.1016/j.atherosclerosis.2013.01.032
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Cardiovascular Product Evaluation Center (심혈관제품유효성평가센터)
Yonsei Authors
권혁문(Kwon, Hyuck Moon)
김종윤(Kim, Jong Youn)
민필기(Min, Pil Ki)
윤영원(Yoon, Young Won)
이다령(Lee, Da Lyung)
이병권(Lee, Byoung Kwon)
임세중(Rim, Se Joong)
정광회(Chung, Kwang Hoe)
조민희(Cho, Min Hee)
최의영(Choi, Eui Young)
홍범기(Hong, Bum Kee)
홍성유(Hong, Sung Yu)
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