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Adiponectin and progression of arterial stiffness in hypertensive patients

Authors
 Jong-Chan Youn  ;  Changsoo Kim  ;  Sungha Park  ;  Sang-Hak Lee  ;  Seok-Min Kang  ;  Donghoon Choi  ;  Nak Hoon Son  ;  Dong-Jik Shin  ;  Yangsoo Jang 
Citation
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.163(3) : 316-319, 2013 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOLOGY 
ISSN
 0167-5273 
Issue Date
2013
MeSH
Adiponectin/blood* ; Adiposity/physiology ; Aged ; Biomarkers/blood ; Cohort Studies ; Disease Progression* ; Female ; Follow-Up Studies ; Humans ; Hypertension/blood ; Hypertension/diagnosis* ; Hypertension/physiopathology* ; Male ; Middle Aged ; Vascular Stiffness/physiology*
Keywords
AdiponectinArterial stiffeningVascular aging
Abstract
BACKGROUND: Recent studies suggest that adiposity is associated with arterial stiffness. However, it is unclear which adipokine or what adiposity related parameters are related with the progression of arterial stiffness. We hypothesized that in hypertensive patients, initial levels of adipokines such as adiponectin and resistin are related to the progression of arterial stiffness, which has been proven to be associated with increased risk of cardiovascular events. METHODS: One hundred forty one consecutive patients with treated essential hypertension (81 men, 57.7±8.2 years) were enrolled. Pulse wave velocity (PWV) was measured at baseline, and after 24 months. Clinical variables and laboratory findings at the time of initial enrollment were analyzed to reveal the determinants of arterial stiffening. RESULTS: Mean heart to femoral PWV (hfPWV) was 992±202 cm/s at baseline, and 1021±263 cm/s at 24 months follow up. hfPWV progressed in seventy two patients (51.1%) during follow up period. In patients with hfPWV progression, mean plasma adiponectin level was significantly lower than patients with nonprogression (progressor: 5.18±3.21 μg/ml, non-progressor: 7.02±5.19 μg/ml, p=0.013). Multivariate regression analysis revealed plasma adiponectin level to being an independent predictor of hfPWV changes (ß=-0.018, p=0.032) when controlled for age, gender, SBP changes, BP control and HOMA. CONCLUSIONS: Plasma adiponectin levels are associated with progression of arterial stiffness in hypertensive patients. These findings may be one explanation for the high association between adiposity and arterial stiffness in hypertensive patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167527311005870
DOI
10.1016/j.ijcard.2011.06.061
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Son, Nak Hoon(손낙훈)
Youn, Jong Chan(윤종찬)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86459
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