Cited 40 times in
Adiponectin and progression of arterial stiffness in hypertensive patients
DC Field | Value | Language |
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dc.contributor.author | 손낙훈 | - |
dc.contributor.author | 윤종찬 | - |
dc.contributor.author | 이상학 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 강석민 | - |
dc.contributor.author | 김창수 | - |
dc.contributor.author | 박성하 | - |
dc.date.accessioned | 2014-12-18T08:31:09Z | - |
dc.date.available | 2014-12-18T08:31:09Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86459 | - |
dc.description.abstract | BACKGROUND: Recent studies suggest that adiposity is associated with arterial stiffness. However, it is unclear which adipokine or what adiposity related parameters are related with the progression of arterial stiffness. We hypothesized that in hypertensive patients, initial levels of adipokines such as adiponectin and resistin are related to the progression of arterial stiffness, which has been proven to be associated with increased risk of cardiovascular events. METHODS: One hundred forty one consecutive patients with treated essential hypertension (81 men, 57.7±8.2 years) were enrolled. Pulse wave velocity (PWV) was measured at baseline, and after 24 months. Clinical variables and laboratory findings at the time of initial enrollment were analyzed to reveal the determinants of arterial stiffening. RESULTS: Mean heart to femoral PWV (hfPWV) was 992±202 cm/s at baseline, and 1021±263 cm/s at 24 months follow up. hfPWV progressed in seventy two patients (51.1%) during follow up period. In patients with hfPWV progression, mean plasma adiponectin level was significantly lower than patients with nonprogression (progressor: 5.18±3.21 μg/ml, non-progressor: 7.02±5.19 μg/ml, p=0.013). Multivariate regression analysis revealed plasma adiponectin level to being an independent predictor of hfPWV changes (ß=-0.018, p=0.032) when controlled for age, gender, SBP changes, BP control and HOMA. CONCLUSIONS: Plasma adiponectin levels are associated with progression of arterial stiffness in hypertensive patients. These findings may be one explanation for the high association between adiposity and arterial stiffness in hypertensive patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiponectin/blood* | - |
dc.subject.MESH | Adiposity/physiology | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Disease Progression* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension/blood | - |
dc.subject.MESH | Hypertension/diagnosis* | - |
dc.subject.MESH | Hypertension/physiopathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Vascular Stiffness/physiology* | - |
dc.title | Adiponectin and progression of arterial stiffness in hypertensive patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biostatistics (의학통계학) | - |
dc.contributor.googleauthor | Jong-Chan Youn | - |
dc.contributor.googleauthor | Changsoo Kim | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Nak Hoon Son | - |
dc.contributor.googleauthor | Dong-Jik Shin | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.identifier.doi | 10.1016/j.ijcard.2011.06.061 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01964 | - |
dc.contributor.localId | A02600 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A01042 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02833 | - |
dc.relation.journalcode | J01093 | - |
dc.identifier.eissn | 1874-1754 | - |
dc.identifier.pmid | 21724272 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0167527311005870 | - |
dc.subject.keyword | AdiponectinArterial stiffeningVascular aging | - |
dc.contributor.alternativeName | Son, Nak Hoon | - |
dc.contributor.alternativeName | Youn, Jong Chan | - |
dc.contributor.alternativeName | Lee, Sang Hak | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.alternativeName | Kim, Chang Soo | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Son, Nak Hoon | - |
dc.contributor.affiliatedAuthor | Youn, Jong Chan | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | Kim, Chang Soo | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Lee, Snag Hak | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 163 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 316 | - |
dc.citation.endPage | 319 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.163(3) : 316-319, 2013 | - |
dc.identifier.rimsid | 28994 | - |
dc.type.rims | ART | - |
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