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Adiponectin and progression of arterial stiffness in hypertensive patients

DC FieldValueLanguage
dc.contributor.author손낙훈-
dc.contributor.author윤종찬-
dc.contributor.author이상학-
dc.contributor.author장양수-
dc.contributor.author최동훈-
dc.contributor.author강석민-
dc.contributor.author김창수-
dc.contributor.author박성하-
dc.date.accessioned2014-12-18T08:31:09Z-
dc.date.available2014-12-18T08:31:09Z-
dc.date.issued2013-
dc.identifier.issn0167-5273-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86459-
dc.description.abstractBACKGROUND: Recent studies suggest that adiposity is associated with arterial stiffness. However, it is unclear which adipokine or what adiposity related parameters are related with the progression of arterial stiffness. We hypothesized that in hypertensive patients, initial levels of adipokines such as adiponectin and resistin are related to the progression of arterial stiffness, which has been proven to be associated with increased risk of cardiovascular events. METHODS: One hundred forty one consecutive patients with treated essential hypertension (81 men, 57.7±8.2 years) were enrolled. Pulse wave velocity (PWV) was measured at baseline, and after 24 months. Clinical variables and laboratory findings at the time of initial enrollment were analyzed to reveal the determinants of arterial stiffening. RESULTS: Mean heart to femoral PWV (hfPWV) was 992±202 cm/s at baseline, and 1021±263 cm/s at 24 months follow up. hfPWV progressed in seventy two patients (51.1%) during follow up period. In patients with hfPWV progression, mean plasma adiponectin level was significantly lower than patients with nonprogression (progressor: 5.18±3.21 μg/ml, non-progressor: 7.02±5.19 μg/ml, p=0.013). Multivariate regression analysis revealed plasma adiponectin level to being an independent predictor of hfPWV changes (ß=-0.018, p=0.032) when controlled for age, gender, SBP changes, BP control and HOMA. CONCLUSIONS: Plasma adiponectin levels are associated with progression of arterial stiffness in hypertensive patients. These findings may be one explanation for the high association between adiposity and arterial stiffness in hypertensive patients.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfInternational Journal of Cardiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdiponectin/blood*-
dc.subject.MESHAdiposity/physiology-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHCohort Studies-
dc.subject.MESHDisease Progression*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHHypertension/blood-
dc.subject.MESHHypertension/diagnosis*-
dc.subject.MESHHypertension/physiopathology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHVascular Stiffness/physiology*-
dc.titleAdiponectin and progression of arterial stiffness in hypertensive patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biostatistics (의학통계학)-
dc.contributor.googleauthorJong-Chan Youn-
dc.contributor.googleauthorChangsoo Kim-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorSang-Hak Lee-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorNak Hoon Son-
dc.contributor.googleauthorDong-Jik Shin-
dc.contributor.googleauthorYangsoo Jang-
dc.identifier.doi10.1016/j.ijcard.2011.06.061-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01964-
dc.contributor.localIdA02600-
dc.contributor.localIdA03448-
dc.contributor.localIdA04053-
dc.contributor.localIdA00037-
dc.contributor.localIdA01042-
dc.contributor.localIdA01512-
dc.contributor.localIdA02833-
dc.relation.journalcodeJ01093-
dc.identifier.pmid21724272-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0167527311005870-
dc.subject.keywordAdiponectinArterial stiffeningVascular aging-
dc.contributor.alternativeNameSon, Nak Hoon-
dc.contributor.alternativeNameYoun, Jong Chan-
dc.contributor.alternativeNameLee, Sang Hak-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNameKim, Chang Soo-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.affiliatedAuthorSon, Nak Hoon-
dc.contributor.affiliatedAuthorYoun, Jong Chan-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.contributor.affiliatedAuthorKim, Chang Soo-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorLee, Snag Hak-
dc.rights.accessRightsnot free-
dc.citation.volume163-
dc.citation.number3-
dc.citation.startPage316-
dc.citation.endPage319-
dc.identifier.bibliographicCitationInternational Journal of Cardiology, Vol.163(3) : 316-319, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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