403 706

Cited 5 times in

Effects of tuberculosis on the kinetics of CD4+ T cell count among HIV-infected patients who initiated antiretroviral therapy early after tuberculosis treatment

Authors
 Nam Su Ku  ;  Jin Ok Oh  ;  So Youn Shin  ;  Sun Bean Kim  ;  Hye-won Kim  ;  Su Jin Jeong  ;  Sang Hoon Han  ;  Young Goo Song  ;  June Myung Kim  ;  Jun Yong Choi 
Citation
 AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol.29(2) : 226-230, 2013 
Journal Title
AIDS RESEARCH AND HUMAN RETROVIRUSES
ISSN
 0889-2229 
Issue Date
2013
MeSH
Adult ; Aged ; Anti-HIV Agents/administration & dosage* ; Antiretroviral Therapy, Highly Active/methods ; Antitubercular Agents/administration & dosage* ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology* ; Case-Control Studies ; Female ; HIV Infections/complications* ; HIV Infections/drug therapy ; HIV Infections/immunology* ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Treatment Outcome ; Tuberculosis/complications* ; Tuberculosis/drug therapy ; Tuberculosis/immunology* ; Viral Load
Keywords
Adult ; Aged ; Anti-HIV Agents/administration & dosage* ; Antiretroviral Therapy, Highly Active/methods ; Antitubercular Agents/administration & dosage* ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology* ; Case-Control Studies ; Female ; HIV Infections/complications* ; HIV Infections/drug therapy ; HIV Infections/immunology* ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Treatment Outcome ; Tuberculosis/complications* ; Tuberculosis/drug therapy ; Tuberculosis/immunology* ; Viral Load
Abstract
The effects of tuberculosis (TB) on the kinetics of CD4(+) T cells among HIV-infected individuals with early combination antiretroviral therapy (cART) after TB therapy initiation are poorly characterized. We conducted a case-control study with 15 HIV-TB-coinfected patients who initiated TB treatment and early cART, and 30 controls without TB who had similar CD4(+) T cell counts and viral loads at the time of starting cART. We compared the rate of CD4(+) T cell increase for 5 years after cART. The time to CD4(+) T cell increase >250 cells/mm(3) was significantly slower in HIV-TB-coinfected patients (p=0.015, by log rank test). HIV-TB-coinfected patients had significantly lower median CD4(+) T cell counts at 5 years after cART (p=0.048). The difference in CD4(+) T cell increase was observed only during the first 6 months after cART initiation (p=0.002). These data suggest that TB slows the rate of CD4(+) T cell recovery at an early period after cART. The effects of TB on the long-term immunity of HIV-infected patients should be further evaluated.
Files in This Item:
T201300320.pdf Download
DOI
10.1089/aid.2012.0192
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Sun Bean(김선빈)
Kim, June Myung(김준명)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Oh, Jin Ok(오진옥)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86368
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links