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Effects of tuberculosis on the kinetics of CD4+ T cell count among HIV-infected patients who initiated antiretroviral therapy early after tuberculosis treatment

Authors
 Nam Su Ku  ;  Jin Ok Oh  ;  So Youn Shin  ;  Sun Bean Kim  ;  Hye-won Kim  ;  Su Jin Jeong  ;  Sang Hoon Han  ;  Young Goo Song  ;  June Myung Kim  ;  Jun Yong Choi 
Citation
 AIDS Research and Human Retroviruses, Vol.29(2) : 226-230, 2013 
Journal Title
 AIDS Research and Human Retroviruses 
ISSN
 0889-2229 
Issue Date
2013
Abstract
The effects of tuberculosis (TB) on the kinetics of CD4(+) T cells among HIV-infected individuals with early combination antiretroviral therapy (cART) after TB therapy initiation are poorly characterized. We conducted a case-control study with 15 HIV-TB-coinfected patients who initiated TB treatment and early cART, and 30 controls without TB who had similar CD4(+) T cell counts and viral loads at the time of starting cART. We compared the rate of CD4(+) T cell increase for 5 years after cART. The time to CD4(+) T cell increase >250 cells/mm(3) was significantly slower in HIV-TB-coinfected patients (p=0.015, by log rank test). HIV-TB-coinfected patients had significantly lower median CD4(+) T cell counts at 5 years after cART (p=0.048). The difference in CD4(+) T cell increase was observed only during the first 6 months after cART initiation (p=0.002). These data suggest that TB slows the rate of CD4(+) T cell recovery at an early period after cART. The effects of TB on the long-term immunity of HIV-infected patients should be further evaluated.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86368
Files in This Item:
T201300320.pdf Download
DOI
10.1089/aid.2012.0192
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
구남수(Ku, Nam Su) ORCID logo https://orcid.org/0000-0002-9717-4327
김선빈(Kim, Sun Bean)
김준명(Kim, June Myung)
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
오진옥(Oh, Jin Ok)
정수진(Jeong, Su Jin)
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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