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Effects of tuberculosis on the kinetics of CD4+ T cell count among HIV-infected patients who initiated antiretroviral therapy early after tuberculosis treatment

DC FieldValueLanguage
dc.contributor.author구남수-
dc.contributor.author김선빈-
dc.contributor.author김준명-
dc.contributor.author송영구-
dc.contributor.author오진옥-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.contributor.author한상훈-
dc.date.accessioned2014-12-18T08:28:17Z-
dc.date.available2014-12-18T08:28:17Z-
dc.date.issued2013-
dc.identifier.issn0889-2229-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86368-
dc.description.abstractThe effects of tuberculosis (TB) on the kinetics of CD4(+) T cells among HIV-infected individuals with early combination antiretroviral therapy (cART) after TB therapy initiation are poorly characterized. We conducted a case-control study with 15 HIV-TB-coinfected patients who initiated TB treatment and early cART, and 30 controls without TB who had similar CD4(+) T cell counts and viral loads at the time of starting cART. We compared the rate of CD4(+) T cell increase for 5 years after cART. The time to CD4(+) T cell increase >250 cells/mm(3) was significantly slower in HIV-TB-coinfected patients (p=0.015, by log rank test). HIV-TB-coinfected patients had significantly lower median CD4(+) T cell counts at 5 years after cART (p=0.048). The difference in CD4(+) T cell increase was observed only during the first 6 months after cART initiation (p=0.002). These data suggest that TB slows the rate of CD4(+) T cell recovery at an early period after cART. The effects of TB on the long-term immunity of HIV-infected patients should be further evaluated.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfAIDS Research and Human Retroviruses-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of tuberculosis on the kinetics of CD4+ T cell count among HIV-infected patients who initiated antiretroviral therapy early after tuberculosis treatment-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorJin Ok Oh-
dc.contributor.googleauthorSo Youn Shin-
dc.contributor.googleauthorSun Bean Kim-
dc.contributor.googleauthorHye-won Kim-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorJune Myung Kim-
dc.contributor.googleauthorJun Yong Choi-
dc.identifier.doi10.1089/aid.2012.0192-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00189-
dc.contributor.localIdA00547-
dc.contributor.localIdA00953-
dc.contributor.localIdA02037-
dc.contributor.localIdA02402-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ00055-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.alternativeNameKim, Sun Bean-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameOh, Jin Ok-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.affiliatedAuthorKu, Nam Su-
dc.contributor.affiliatedAuthorKim, Sun Bean-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorOh, Jin Ok-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.rights.accessRightsfree-
dc.citation.volume29-
dc.citation.number2-
dc.citation.startPage226-
dc.citation.endPage230-
dc.identifier.bibliographicCitationAIDS Research and Human Retroviruses, Vol.29(2) : 226-230, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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