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Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment

Authors
 Sang Hoon Han  ;  Seung Up Kim  ;  Chang Oh Kim  ;  Su Jin Jeong  ;  Jun Yong Park  ;  Jun Yong Choi  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Young Goo Song  ;  Kwang-Hyub Han  ;  June Myung Kim 
Citation
 PLoS One, Vol.8(1) : e52720, 2013 
Journal Title
 PLoS One 
ISSN
 1932-6203 
Issue Date
2013
Abstract
BACKGROUND AND AIMS: Liver stiffness measurement (LSM) using transient elastography (Fibroscan®) can identify individuals with potential underlying liver disease. We evaluated the prevalence of abnormal LSM values as assessed using LSM and its predictors in HIV-infected asymptomatic patients receiving combined antiretroviral treatment (cART) without HBV/HCV coinfection. METHODS: We prospectively recruited 93 patients who had consistently been undergoing cART for more than 12 months at Severance Hospital in Seoul, Republic of Korea, from June to December 2010. LSM values >5.3 kPa were defined as abnormal. RESULTS: Thirty-nine (41.9%) had abnormal LSM values. On multivariate correlation analysis, the cumulative duration of boosted and unboosted protease inhibitors (PIs) were the independent factors which showed a negative and positive correlation to LSM values, respectively (β = -0.234, P = 0.023 and β = 0.430, P<0.001). In multivariate logistic regression analysis, the cumulative exposure duration of boosted-PIs and γ-glutamyltranspeptidase levels were selected as the independent predictors which showed a negative and positive correlation with abnormal LSM values, respectively (odds ratio [OR], 0.941; 95% confidence interval [CI], 0.889-0.997; P = 0.039 and OR, 1.032; 95% CI, 1.004-1.060; P = 0.023). CONCLUSION: The high percentage of HIV-infected asymptomatic patients receiving cART without HBV/HCV coinfection had abnormal LSM values. The cumulative exposure duration of boosted-PIs and γ-GT level were independent predictors which showed a negative and positive correlation with abnormal LSM values, respectively.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86356
Files in This Item:
T201300306.pdf Download
DOI
10.1371/journal.pone.0052720
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김도영(Kim, Do Young)
김승업(Kim, Seung Up)
김준명(Kim, June Myung)
김창오(Kim, Chang Oh) ORCID logo https://orcid.org/0000-0002-0773-5443
박준용(Park, Jun Yong) ORCID logo https://orcid.org/0000-0001-6324-2224
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
안상훈(Ahn, Sang Hoon)
정수진(Jeong, Su Jin)
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
한광협(Han, Kwang Hyup)
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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