Cited 24 times in
Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment
DC Field | Value | Language |
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dc.contributor.author | 한상훈 | - |
dc.contributor.author | 김준명 | - |
dc.contributor.author | 김창오 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 송영구 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 최준용 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | 김승업 | - |
dc.contributor.author | 김도영 | - |
dc.date.accessioned | 2014-12-18T08:27:54Z | - |
dc.date.available | 2014-12-18T08:27:54Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86356 | - |
dc.description.abstract | BACKGROUND AND AIMS: Liver stiffness measurement (LSM) using transient elastography (Fibroscan®) can identify individuals with potential underlying liver disease. We evaluated the prevalence of abnormal LSM values as assessed using LSM and its predictors in HIV-infected asymptomatic patients receiving combined antiretroviral treatment (cART) without HBV/HCV coinfection. METHODS: We prospectively recruited 93 patients who had consistently been undergoing cART for more than 12 months at Severance Hospital in Seoul, Republic of Korea, from June to December 2010. LSM values >5.3 kPa were defined as abnormal. RESULTS: Thirty-nine (41.9%) had abnormal LSM values. On multivariate correlation analysis, the cumulative duration of boosted and unboosted protease inhibitors (PIs) were the independent factors which showed a negative and positive correlation to LSM values, respectively (β = -0.234, P = 0.023 and β = 0.430, P<0.001). In multivariate logistic regression analysis, the cumulative exposure duration of boosted-PIs and γ-glutamyltranspeptidase levels were selected as the independent predictors which showed a negative and positive correlation with abnormal LSM values, respectively (odds ratio [OR], 0.941; 95% confidence interval [CI], 0.889-0.997; P = 0.039 and OR, 1.032; 95% CI, 1.004-1.060; P = 0.023). CONCLUSION: The high percentage of HIV-infected asymptomatic patients receiving cART without HBV/HCV coinfection had abnormal LSM values. The cumulative exposure duration of boosted-PIs and γ-GT level were independent predictors which showed a negative and positive correlation with abnormal LSM values, respectively. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sang Hoon Han | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.contributor.googleauthor | Chang Oh Kim | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Young Goo Song | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | June Myung Kim | - |
dc.identifier.doi | 10.1371/journal.pone.0052720 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04286 | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A01044 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.contributor.alternativeName | Han, Sang Hoon | - |
dc.contributor.alternativeName | Kim, June Myung | - |
dc.contributor.alternativeName | Kim, Chang Oh | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.alternativeName | Song, Young Goo | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Jeong, Su Jin | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.affiliatedAuthor | Han, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Kim, June Myung | - |
dc.contributor.affiliatedAuthor | Kim, Chang Oh | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Song, Young Goo | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Jeong, Su Jin | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | e52720 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.8(1) : e52720, 2013 | - |
dc.identifier.rimsid | 28932 | - |
dc.type.rims | ART | - |
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