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Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment

DC FieldValueLanguage
dc.contributor.author한상훈-
dc.contributor.author김준명-
dc.contributor.author김창오-
dc.contributor.author박준용-
dc.contributor.author송영구-
dc.contributor.author안상훈-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.contributor.author한광협-
dc.contributor.author김승업-
dc.contributor.author김도영-
dc.date.accessioned2014-12-18T08:27:54Z-
dc.date.available2014-12-18T08:27:54Z-
dc.date.issued2013-
dc.identifier.issn1932-6203-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86356-
dc.description.abstractBACKGROUND AND AIMS: Liver stiffness measurement (LSM) using transient elastography (Fibroscan®) can identify individuals with potential underlying liver disease. We evaluated the prevalence of abnormal LSM values as assessed using LSM and its predictors in HIV-infected asymptomatic patients receiving combined antiretroviral treatment (cART) without HBV/HCV coinfection. METHODS: We prospectively recruited 93 patients who had consistently been undergoing cART for more than 12 months at Severance Hospital in Seoul, Republic of Korea, from June to December 2010. LSM values >5.3 kPa were defined as abnormal. RESULTS: Thirty-nine (41.9%) had abnormal LSM values. On multivariate correlation analysis, the cumulative duration of boosted and unboosted protease inhibitors (PIs) were the independent factors which showed a negative and positive correlation to LSM values, respectively (β = -0.234, P = 0.023 and β = 0.430, P<0.001). In multivariate logistic regression analysis, the cumulative exposure duration of boosted-PIs and γ-glutamyltranspeptidase levels were selected as the independent predictors which showed a negative and positive correlation with abnormal LSM values, respectively (odds ratio [OR], 0.941; 95% confidence interval [CI], 0.889-0.997; P = 0.039 and OR, 1.032; 95% CI, 1.004-1.060; P = 0.023). CONCLUSION: The high percentage of HIV-infected asymptomatic patients receiving cART without HBV/HCV coinfection had abnormal LSM values. The cumulative exposure duration of boosted-PIs and γ-GT level were independent predictors which showed a negative and positive correlation with abnormal LSM values, respectively.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAbnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorChang Oh Kim-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.1371/journal.pone.0052720-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04286-
dc.contributor.localIdA00953-
dc.contributor.localIdA01044-
dc.contributor.localIdA01675-
dc.contributor.localIdA02037-
dc.contributor.localIdA02226-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.contributor.localIdA04268-
dc.contributor.localIdA00654-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ02540-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.rights.accessRightsfree-
dc.citation.volume8-
dc.citation.number1-
dc.citation.startPagee52720-
dc.identifier.bibliographicCitationPLoS One, Vol.8(1) : e52720, 2013-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)

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