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Effects of Ramosetron on Gastrointestinal Transit of Guinea Pig

 Yoo Mi Park  ;  Young Ju Lee  ;  Young Ho Lee  ;  Tae Il Kim  ;  Hyojin Park 
 Journal of Neurogastroenterology and Motility, Vol.19(1) : 36-41, 2013 
Journal Title
 Journal of Neurogastroenterology and Motility 
Issue Date
Background/Aims A selective 5-hydroxytryptamine (5-HT) type 3 receptor antagonist, ramosetron, inhibits stress-induced abnormal defecation in animals and is currently used as a therapeutic drug for irritable bowel syndrome with diarrhea. The aim of this study is to investigate the effect of ramosetron on altered gastrointestinal (GI) transit. Methods Male guinea pigs weighing approximately 300 g were used. The effect of ramosetron was investigated on altered GI transit induced by thyrotropin-releasing hormone (TRH), 5-HT, or mustard oil (MO). GI transit was evaluated by the migration of charcoal mixture from the pylorus to the most distal point, and expressed as a percentage (%) of charcoal migration (cm) of the total length of total small intestine (cm). Results The average charcoal transit was 51.3 ± 20.1% in the control (vehicle) group, whereas in the ramosetron group charcoal moved 56.6 ± 21.9%, 46.9 ± 9.14% and 8.4 ± 5.6% of the total small intestine at the concentrations of 10, 30 and 100 ?g/kg, respectively. GI transit after administration of TRH (100 ?g/kg), 5-HT (10 mg/kg) or MO (10 mg/kg) was accelerated compared to vehicle (5-HT, 94.9 ± 9.22%; TRH, 73.4 ± 14.7%; MO, 81.0 ± 13.7%). Ramosetron inhibited GI transit altered by 5-HT, TRH or MO. Conclusions Ramosetron modulated GI transit. We suggest that ramosetron may be therapeutically useful for those with accelerated upper GI transit.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김태일(Kim, Tae Il) ORCID logo https://orcid.org/0000-0003-4807-890X
박유미(Park, Yoo Mi)
박효진(Park, Hyo Jin)
이영주(Lee, Young Joo)
이영호(Lee, Young Ho) ORCID logo https://orcid.org/0000-0002-5749-1045
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