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Cited 2 times in

Effects of Ramosetron on Gastrointestinal Transit of Guinea Pig

DC FieldValueLanguage
dc.contributor.author김태일-
dc.contributor.author박유미-
dc.contributor.author박효진-
dc.contributor.author이영주-
dc.contributor.author이영호-
dc.date.accessioned2014-12-18T08:27:05Z-
dc.date.available2014-12-18T08:27:05Z-
dc.date.issued2013-
dc.identifier.issn2093-0879-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86331-
dc.description.abstractBackground/Aims A selective 5-hydroxytryptamine (5-HT) type 3 receptor antagonist, ramosetron, inhibits stress-induced abnormal defecation in animals and is currently used as a therapeutic drug for irritable bowel syndrome with diarrhea. The aim of this study is to investigate the effect of ramosetron on altered gastrointestinal (GI) transit. Methods Male guinea pigs weighing approximately 300 g were used. The effect of ramosetron was investigated on altered GI transit induced by thyrotropin-releasing hormone (TRH), 5-HT, or mustard oil (MO). GI transit was evaluated by the migration of charcoal mixture from the pylorus to the most distal point, and expressed as a percentage (%) of charcoal migration (cm) of the total length of total small intestine (cm). Results The average charcoal transit was 51.3 ± 20.1% in the control (vehicle) group, whereas in the ramosetron group charcoal moved 56.6 ± 21.9%, 46.9 ± 9.14% and 8.4 ± 5.6% of the total small intestine at the concentrations of 10, 30 and 100 ?g/kg, respectively. GI transit after administration of TRH (100 ?g/kg), 5-HT (10 mg/kg) or MO (10 mg/kg) was accelerated compared to vehicle (5-HT, 94.9 ± 9.22%; TRH, 73.4 ± 14.7%; MO, 81.0 ± 13.7%). Ramosetron inhibited GI transit altered by 5-HT, TRH or MO. Conclusions Ramosetron modulated GI transit. We suggest that ramosetron may be therapeutically useful for those with accelerated upper GI transit.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of Ramosetron on Gastrointestinal Transit of Guinea Pig-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Physiology (생리학)-
dc.contributor.googleauthorYoo Mi Park-
dc.contributor.googleauthorYoung Ju Lee-
dc.contributor.googleauthorYoung Ho Lee-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorHyojin Park-
dc.identifier.doi10.5056/jnm.2013.19.1.36-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01079-
dc.contributor.localIdA01774-
dc.contributor.localIdA02960-
dc.contributor.localIdA02968-
dc.contributor.localIdA04937-
dc.relation.journalcodeJ01623-
dc.identifier.eissn2093-0887-
dc.identifier.pmid23350045-
dc.subject.keywordGastrointestinal transit-
dc.subject.keywordMustard oil-
dc.subject.keywordRamosetron-
dc.subject.keywordSerotonin 5-HT3 receptor antagonist-
dc.subject.keywordThyrotropin-releasing hormone-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNamePark, Yoo Mi-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.alternativeNameLee, Young Joo-
dc.contributor.alternativeNameLee, Young Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.contributor.affiliatedAuthorLee, Young Joo-
dc.contributor.affiliatedAuthorLee, Young Ho-
dc.contributor.affiliatedAuthorPark, Yoo Mi-
dc.rights.accessRightsfree-
dc.citation.volume19-
dc.citation.number1-
dc.citation.startPage36-
dc.citation.endPage41-
dc.identifier.bibliographicCitationJOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, Vol.19(1) : 36-41, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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