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An orthotopic and osteolytic model with a newly established oral squamous cell carcinoma cell line

Authors
 Young Sun Hwang  ;  Xianglan Zhang  ;  Kwang-Kyun Park  ;  Won-Yoon Chung 
Citation
 Archives of Oral Biology, Vol.58(2) : 218-225, 2013 
Journal Title
 Archives of Oral Biology 
ISSN
 0003-9969 
Issue Date
2013
Abstract
OBJECTIVE: Despite the availability of advanced clinical diagnostic systems, the overall 5-year survival rate for patients with oral squamous cell carcinoma (OSCC) has remained relatively poor over the past 2 decades. Appropriate animal models need to be developed according to the specific purpose of cancer research. However, most of the currently available oral cancer cell lines do not precisely reflect the characteristics of bone-invasive OSCC and cannot serve as suitable tools in the development of new therapeutic reagents against bone-invasive OSCC. Here, we assessed the orthotopic and osteolytic mouse model with newly established OSCC cell line. DESIGN: We assessed the orthotopic and osteolytic mouse model using the newly established OSCC cells. In addition, the incidences of tumorigenesis and histopathological results were determined. RESULTS: The newly established YD-39 cell line grows in a monolayer sheet and has highly invasive. The transplanted YD-39 cells developed stable tumours in the tongues and calvaria region of the nude mice. The tumours in nude mice grafted with YD-39 cells had a high incidence of transplantability in both mouse models tested and a similar morphology to their respective original tumour. Therefore, both animal models might be feasible animal models to assess the efficacy of anti-cancer drugs. CONCLUSIONS: This type of animal model approach might be has the added advantage of potentially accelerating the biological discovery process.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86304
Full Text
http://www.sciencedirect.com/science/article/pii/S0003996912001471
DOI
10.1016/j.archoralbio.2012.04.023
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
Yonsei Authors
박광균(Park, Kwang Kyun)
장향란(Zhang, Xiang Lan)
정원윤(Chung, Won Yoon) ORCID logo https://orcid.org/0000-0001-8428-9005
황영선(Hwang, Young Sun)
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