3 204

Cited 28 times in

Combination of Pregabalin and Dexamethasone for Postoperative Pain and Functional Outcome in Patients Undergoing Lumbar Spinal Surgery: A Randomized Placebo-controlled Trial

 Choi Yong Seon  ;  Shim Jae-Kwang  ;  Song Jong Wook  ;  Kim Jong Chan  ;  Yoo Young Chul  ;  Kwak Young Lan 
 CLINICAL JOURNAL OF PAIN, Vol.29(1) : 9-14, 2013 
Journal Title
Issue Date
Activities of Daily Living ; Adult ; Aged ; Analgesics/administration & dosage ; Anti-Inflammatory Agents/administration & dosage ; Dexamethasone/administration & dosage* ; Drug Therapy, Combination ; Female ; Humans ; Laminectomy/statistics & numerical data* ; Lumbar Vertebrae/surgery* ; Male ; Middle Aged ; Pain Measurement/drug effects ; Pain Measurement/statistics & numerical data ; Pain, Postoperative/diagnosis ; Pain, Postoperative/drug therapy* ; Pain, Postoperative/epidemiology ; Placebo Effect ; Pregabalin ; Premedication/methods ; Premedication/utilization* ; Recovery of Function ; Republic of Korea/epidemiology ; Treatment Outcome ; Young Adult ; gamma-Aminobutyric Acid/administration & dosage ; gamma-Aminobutyric Acid/analogs & derivatives*
dexamethasone ; postoperative pain ; pregabalin
OBJECTIVES: In this randomized-controlled study, we investigated the effects of combined administration of pregabalin and dexamethasone on postoperative pain and analgesic requirements, and functional outcome in patients who underwent lumbar spinal surgery. METHODS: One hundred eight patients were randomized to group C (placebo+placebo), group P (pregabalin + placebo), or group PD (pregabalin+dexamethasone). According to their allocated group, patients received placebo or pregabalin 150 mg every 12 hours starting 1 hour before anesthetic induction for a total of 8 doses. Dexamethasone 16 mg or normal saline was injected before the induction of anesthesia. The pain intensity, analgesic requirements, and side effects were assessed in the postoperative period: postanesthesia care unit, 12, 24, 48, and 72 hours. Pain intensity and daily activity performance were also assessed 1, 3, and 6 months after surgery. RESULTS: Compared with group C, the pain scores were lower in group PD at 24 hours after surgery (P = 0.011). The frequency of additional rescue analgesic administration was significantly lower in group PD until 48 hours after surgery (P < 0.05) and in group P at 24 to 48 hours (P = 0.005) relative to group C. Back pain intensity at work was lower (P = 0.048) and daily activity performance was better (P = 0.006) in group PD compared with group C at 1 month after surgery. CONCLUSIONS: Combined administration of pregabalin and dexamethasone conferred analgesic benefits superior to those of pregabalin alone. This regimen also helped facilitate return to normal daily activity after surgery.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Song, Jong Wook(송종욱) ORCID logo https://orcid.org/0000-0001-7518-2070
Shim, Jae Kwang(심재광) ORCID logo https://orcid.org/0000-0001-9093-9692
Yoo, Young Chul(유영철) ORCID logo https://orcid.org/0000-0002-6334-7541
Choi, Yong Seon(최용선) ORCID logo https://orcid.org/0000-0002-5348-864X
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.