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Combination of Pregabalin and Dexamethasone for Postoperative Pain and Functional Outcome in Patients Undergoing Lumbar Spinal Surgery: A Randomized Placebo-controlled Trial

DC FieldValueLanguage
dc.contributor.author송종욱-
dc.contributor.author심재광-
dc.contributor.author유영철-
dc.contributor.author최용선-
dc.contributor.author곽영란-
dc.date.accessioned2014-12-18T08:23:42Z-
dc.date.available2014-12-18T08:23:42Z-
dc.date.issued2013-
dc.identifier.issn0749-8047-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86224-
dc.description.abstractOBJECTIVES: In this randomized-controlled study, we investigated the effects of combined administration of pregabalin and dexamethasone on postoperative pain and analgesic requirements, and functional outcome in patients who underwent lumbar spinal surgery. METHODS: One hundred eight patients were randomized to group C (placebo+placebo), group P (pregabalin + placebo), or group PD (pregabalin+dexamethasone). According to their allocated group, patients received placebo or pregabalin 150 mg every 12 hours starting 1 hour before anesthetic induction for a total of 8 doses. Dexamethasone 16 mg or normal saline was injected before the induction of anesthesia. The pain intensity, analgesic requirements, and side effects were assessed in the postoperative period: postanesthesia care unit, 12, 24, 48, and 72 hours. Pain intensity and daily activity performance were also assessed 1, 3, and 6 months after surgery. RESULTS: Compared with group C, the pain scores were lower in group PD at 24 hours after surgery (P = 0.011). The frequency of additional rescue analgesic administration was significantly lower in group PD until 48 hours after surgery (P < 0.05) and in group P at 24 to 48 hours (P = 0.005) relative to group C. Back pain intensity at work was lower (P = 0.048) and daily activity performance was better (P = 0.006) in group PD compared with group C at 1 month after surgery. CONCLUSIONS: Combined administration of pregabalin and dexamethasone conferred analgesic benefits superior to those of pregabalin alone. This regimen also helped facilitate return to normal daily activity after surgery.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCLINICAL JOURNAL OF PAIN-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHActivities of Daily Living-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnalgesics/administration & dosage-
dc.subject.MESHAnti-Inflammatory Agents/administration & dosage-
dc.subject.MESHDexamethasone/administration & dosage*-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLaminectomy/statistics & numerical data*-
dc.subject.MESHLumbar Vertebrae/surgery*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPain Measurement/drug effects-
dc.subject.MESHPain Measurement/statistics & numerical data-
dc.subject.MESHPain, Postoperative/diagnosis-
dc.subject.MESHPain, Postoperative/drug therapy*-
dc.subject.MESHPain, Postoperative/epidemiology-
dc.subject.MESHPlacebo Effect-
dc.subject.MESHPregabalin-
dc.subject.MESHPremedication/methods-
dc.subject.MESHPremedication/utilization*-
dc.subject.MESHRecovery of Function-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.subject.MESHgamma-Aminobutyric Acid/administration & dosage-
dc.subject.MESHgamma-Aminobutyric Acid/analogs & derivatives*-
dc.titleCombination of Pregabalin and Dexamethasone for Postoperative Pain and Functional Outcome in Patients Undergoing Lumbar Spinal Surgery: A Randomized Placebo-controlled Trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorChoi Yong Seon-
dc.contributor.googleauthorShim Jae-Kwang-
dc.contributor.googleauthorSong Jong Wook-
dc.contributor.googleauthorKim Jong Chan-
dc.contributor.googleauthorYoo Young Chul-
dc.contributor.googleauthorKwak Young Lan-
dc.identifier.doi10.1097/AJP.0b013e318246d1a9-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02060-
dc.contributor.localIdA02205-
dc.contributor.localIdA02484-
dc.contributor.localIdA04119-
dc.contributor.localIdA00172-
dc.relation.journalcodeJ00583-
dc.identifier.eissn1536-5409-
dc.identifier.pmid22751028-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00002508-201301000-00003&LSLINK=80&D=ovft-
dc.subject.keyworddexamethasone-
dc.subject.keywordpostoperative pain-
dc.subject.keywordpregabalin-
dc.contributor.alternativeNameSong, Jong Wook-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.alternativeNameYoo, Young Chul-
dc.contributor.alternativeNameChoi, Yong Seon-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.affiliatedAuthorSong, Jong Wook-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorYoo, Young Chul-
dc.contributor.affiliatedAuthorChoi, Yong Seon-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.rights.accessRightsnot free-
dc.citation.volume29-
dc.citation.number1-
dc.citation.startPage9-
dc.citation.endPage14-
dc.identifier.bibliographicCitationCLINICAL JOURNAL OF PAIN, Vol.29(1) : 9-14, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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