Cited 43 times in
Combination of Pregabalin and Dexamethasone for Postoperative Pain and Functional Outcome in Patients Undergoing Lumbar Spinal Surgery: A Randomized Placebo-controlled Trial
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송종욱 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 유영철 | - |
dc.contributor.author | 최용선 | - |
dc.contributor.author | 곽영란 | - |
dc.date.accessioned | 2014-12-18T08:23:42Z | - |
dc.date.available | 2014-12-18T08:23:42Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0749-8047 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86224 | - |
dc.description.abstract | OBJECTIVES: In this randomized-controlled study, we investigated the effects of combined administration of pregabalin and dexamethasone on postoperative pain and analgesic requirements, and functional outcome in patients who underwent lumbar spinal surgery. METHODS: One hundred eight patients were randomized to group C (placebo+placebo), group P (pregabalin + placebo), or group PD (pregabalin+dexamethasone). According to their allocated group, patients received placebo or pregabalin 150 mg every 12 hours starting 1 hour before anesthetic induction for a total of 8 doses. Dexamethasone 16 mg or normal saline was injected before the induction of anesthesia. The pain intensity, analgesic requirements, and side effects were assessed in the postoperative period: postanesthesia care unit, 12, 24, 48, and 72 hours. Pain intensity and daily activity performance were also assessed 1, 3, and 6 months after surgery. RESULTS: Compared with group C, the pain scores were lower in group PD at 24 hours after surgery (P = 0.011). The frequency of additional rescue analgesic administration was significantly lower in group PD until 48 hours after surgery (P < 0.05) and in group P at 24 to 48 hours (P = 0.005) relative to group C. Back pain intensity at work was lower (P = 0.048) and daily activity performance was better (P = 0.006) in group PD compared with group C at 1 month after surgery. CONCLUSIONS: Combined administration of pregabalin and dexamethasone conferred analgesic benefits superior to those of pregabalin alone. This regimen also helped facilitate return to normal daily activity after surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CLINICAL JOURNAL OF PAIN | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Activities of Daily Living | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Analgesics/administration & dosage | - |
dc.subject.MESH | Anti-Inflammatory Agents/administration & dosage | - |
dc.subject.MESH | Dexamethasone/administration & dosage* | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Laminectomy/statistics & numerical data* | - |
dc.subject.MESH | Lumbar Vertebrae/surgery* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pain Measurement/drug effects | - |
dc.subject.MESH | Pain Measurement/statistics & numerical data | - |
dc.subject.MESH | Pain, Postoperative/diagnosis | - |
dc.subject.MESH | Pain, Postoperative/drug therapy* | - |
dc.subject.MESH | Pain, Postoperative/epidemiology | - |
dc.subject.MESH | Placebo Effect | - |
dc.subject.MESH | Pregabalin | - |
dc.subject.MESH | Premedication/methods | - |
dc.subject.MESH | Premedication/utilization* | - |
dc.subject.MESH | Recovery of Function | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.subject.MESH | gamma-Aminobutyric Acid/administration & dosage | - |
dc.subject.MESH | gamma-Aminobutyric Acid/analogs & derivatives* | - |
dc.title | Combination of Pregabalin and Dexamethasone for Postoperative Pain and Functional Outcome in Patients Undergoing Lumbar Spinal Surgery: A Randomized Placebo-controlled Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Choi Yong Seon | - |
dc.contributor.googleauthor | Shim Jae-Kwang | - |
dc.contributor.googleauthor | Song Jong Wook | - |
dc.contributor.googleauthor | Kim Jong Chan | - |
dc.contributor.googleauthor | Yoo Young Chul | - |
dc.contributor.googleauthor | Kwak Young Lan | - |
dc.identifier.doi | 10.1097/AJP.0b013e318246d1a9 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02060 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A02484 | - |
dc.contributor.localId | A04119 | - |
dc.contributor.localId | A00172 | - |
dc.relation.journalcode | J00583 | - |
dc.identifier.eissn | 1536-5409 | - |
dc.identifier.pmid | 22751028 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00002508-201301000-00003&LSLINK=80&D=ovft | - |
dc.subject.keyword | dexamethasone | - |
dc.subject.keyword | postoperative pain | - |
dc.subject.keyword | pregabalin | - |
dc.contributor.alternativeName | Song, Jong Wook | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.alternativeName | Yoo, Young Chul | - |
dc.contributor.alternativeName | Choi, Yong Seon | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Song, Jong Wook | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Yoo, Young Chul | - |
dc.contributor.affiliatedAuthor | Choi, Yong Seon | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 9 | - |
dc.citation.endPage | 14 | - |
dc.identifier.bibliographicCitation | CLINICAL JOURNAL OF PAIN, Vol.29(1) : 9-14, 2013 | - |
dc.identifier.rimsid | 28857 | - |
dc.type.rims | ART | - |
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