Cited 0 times in

96 3

Distinct TLR-mediated pathways regulate house dust mite–induced allergic disease in the upper and lower airways

Authors
 Ji-Hwan Ryu ; Jung-Yeon Yoo ; Yun Soo Bae ; Joo-Heon Yoon ; Mi-Na Kweon ; Dong Min Shin ; Jaesang Kim ; Won-Jae Lee ; Sang-Nam Lee ; Chang-Hoon Kim ; Jung Hee Joo ; Mi-Kyung Choi ; Jae-Chan Ryu ; Kwang Chul Ahn ; Sang-Gyu Hwang ; Min-Ji Kim 
Citation
 Journal of Allergy and Clinical Immunology, Vol.131(2) : 549~561, 2013 
Journal Title
 Journal of Allergy and Clinical Immunology 
ISSN
 0091-6749 
Issue Date
2013
Abstract
BACKGROUND: Allergic rhinitis (AR) and asthma are 2 entities of allergic airway diseases that frequently occur together, which is referred to as united airways. In contrast to this general concept, we hypothesized that innate immunity of the upper and lower airways is respectively distinctive, because the immunologic conditions of the nasal and lung mucosa as well as the functions of the immune cells within their epithelia are different. OBJECTIVE: We wanted to identify distinctive mechanisms of innate immunity in the nose and lung mucosa, which are responsible for house dust mite (HDM)-induced AR and allergic asthma (AA), respectively. METHODS: We constructed a mouse model of AR or AA induced by sensitization and consequent provocation with HDM extracts. RESULTS: HDM-derived β-glucans, rather than LPS, were proven to be essential to activating innate immunity in the nasal mucosa and triggering AR, which depended on Toll-like receptor 2 (TLR2), but not on TLR4; however, the LPS/TLR4 signaling axis, rather than β-glucans/TLR2, was critical to HDM-induced AA. These differences were attributed to the specific role of β-glucans and LPS in inducing the surface expression of TLR2 and TLR4 and their translocation to lipid rafts in nasal and bronchial epithelial cells, respectively. We also showed that dual oxidase 2-generated reactive oxygen species mediate both β-glucan-induced TLR2 activation and LPS-induced TLR4 activation. CONCLUSIONS: We describe a novel finding of distinctive innate immunity of the nose and lungs, respectively, which trigger AR and AA, by showing the critical role of HDM-induced TLR activation via dual oxidase 2-mediated reactive oxygen species.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86218
DOI
10.1016/j.jaci.2012.07.050
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
1. 연구논문 > 1. College of Medicine > Dept. of Otorhinolaryngology
1. 연구논문 > 5. Research Institutes > 생체방어연구센터
1. 연구논문 > 5. Research Institutes > 생체방어연구센터
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://www.sciencedirect.com/science/article/pii/S0091674912013012
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse