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Therapeutic Lifestyle Modification Program Reduces Plasma Levels of the Chemokines CRP and MCP-1 in Subjects With Metabolic Syndrome

Authors
 Eui Geum Oh ; So Youn Bang ; Mi Kyung Lee ; Jung Eun Lee ; Jee Aee Im ; Justin Y. Jeon ; Sang Hui Chu ; Sa Saeng Hyun ; Soo Hyun Kim 
Citation
 Biological Research for Nursing, Vol.15(1) : 48~55, 2013 
Journal Title
 Biological Research for Nursing 
ISSN
 1099-8004 
Issue Date
2013
Abstract
OBJECTIVE: The purpose of this study was to examine the effects of a 6-month therapeutic lifestyle modification (TLM) program on chemokines related to oxidative stress, inflammation, endothelial dysfunction, and arterial stiffness in subjects with metabolic syndrome (MetS). METHODS: The authors performed a randomized controlled trial, assigning 52 women (mean age 62.7 ± 9.0 years) with MetS to a TLM intervention group (n = 31) or a control group (n = 21). The authors provided the TLM intervention group with health screening, exercise, low-calorie diet, and health education and counseling for 6 months and instructed the control group to maintain their usual lifestyle behaviors. Outcome variables included levels of myeloperoxidase (MPO), oxidized low-density lipoprotein (LDL), adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1β, interleukin-6, tumor necrosis factor-alpha (TNF-α), CD40L, monocyte chemotactic protein-1 (MCP-1), retinol-binding protein 4 (RBP-4), endothelin-1, and brachial-ankle pulse wave velocity. The authors used generalized estimating equation (GEE) analyses to estimate the effects of the TLM program. RESULTS: After the 6-month TLM program, hs-CRP levels decreased significantly, and MCP-1 levels increased at a significantly slower rate in the TLM group than they did in the control group (all p < .05). CONCLUSION: These results indicate that a TLM program could be effective for improving patient inflammatory states and may also be effective in preventing cardiovascular complications in subjects with MetS.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86190
DOI
10.1177/1099800411416637
Appears in Collections:
1. 연구논문 > 3. College of Nursing > Dept. of Nursing Environment Systems
Yonsei Authors
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Link
 http://brn.sagepub.com/content/15/1/48.long
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