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Therapeutic Lifestyle Modification Program Reduces Plasma Levels of the Chemokines CRP and MCP-1 in Subjects With Metabolic Syndrome

DC FieldValueLanguage
dc.contributor.author오의금-
dc.contributor.author추상희-
dc.date.accessioned2014-12-18T08:22:34Z-
dc.date.available2014-12-18T08:22:34Z-
dc.date.issued2013-
dc.identifier.issn1099-8004-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86190-
dc.description.abstractOBJECTIVE: The purpose of this study was to examine the effects of a 6-month therapeutic lifestyle modification (TLM) program on chemokines related to oxidative stress, inflammation, endothelial dysfunction, and arterial stiffness in subjects with metabolic syndrome (MetS). METHODS: The authors performed a randomized controlled trial, assigning 52 women (mean age 62.7 ± 9.0 years) with MetS to a TLM intervention group (n = 31) or a control group (n = 21). The authors provided the TLM intervention group with health screening, exercise, low-calorie diet, and health education and counseling for 6 months and instructed the control group to maintain their usual lifestyle behaviors. Outcome variables included levels of myeloperoxidase (MPO), oxidized low-density lipoprotein (LDL), adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1β, interleukin-6, tumor necrosis factor-alpha (TNF-α), CD40L, monocyte chemotactic protein-1 (MCP-1), retinol-binding protein 4 (RBP-4), endothelin-1, and brachial-ankle pulse wave velocity. The authors used generalized estimating equation (GEE) analyses to estimate the effects of the TLM program. RESULTS: After the 6-month TLM program, hs-CRP levels decreased significantly, and MCP-1 levels increased at a significantly slower rate in the TLM group than they did in the control group (all p < .05). CONCLUSION: These results indicate that a TLM program could be effective for improving patient inflammatory states and may also be effective in preventing cardiovascular complications in subjects with MetS.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfBiological Research for Nursing-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleTherapeutic Lifestyle Modification Program Reduces Plasma Levels of the Chemokines CRP and MCP-1 in Subjects With Metabolic Syndrome-
dc.typeArticle-
dc.contributor.collegeCollege of Nursing (간호대학)-
dc.contributor.departmentDept. of Nursing Environment Systems (임상간호과학과)-
dc.contributor.googleauthorEui Geum Oh-
dc.contributor.googleauthorSo Youn Bang-
dc.contributor.googleauthorSoo Hyun Kim-
dc.contributor.googleauthorSa Saeng Hyun-
dc.contributor.googleauthorSang Hui Chu-
dc.contributor.googleauthorJustin Y. Jeon-
dc.contributor.googleauthorJee Aee Im-
dc.contributor.googleauthorJung Eun Lee-
dc.contributor.googleauthorMi Kyung Lee-
dc.identifier.doi10.1177/1099800411416637-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02393-
dc.contributor.localIdA04232-
dc.relation.journalcodeJ00304-
dc.identifier.urlhttp://brn.sagepub.com/content/15/1/48.long-
dc.contributor.alternativeNameOh, Eui Geum-
dc.contributor.alternativeNameChoo, Sang Hee-
dc.contributor.affiliatedAuthorOh, Eui Geum-
dc.contributor.affiliatedAuthorChoo, Sang Hee-
dc.rights.accessRightsnot free-
dc.citation.volume15-
dc.citation.number1-
dc.citation.startPage48-
dc.citation.endPage55-
dc.identifier.bibliographicCitationBiological Research for Nursing, Vol.15(1) : 48-55, 2013-
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers

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