Cited 24 times in
Therapeutic Lifestyle Modification Program Reduces Plasma Levels of the Chemokines CRP and MCP-1 in Subjects With Metabolic Syndrome
DC Field | Value | Language |
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dc.contributor.author | 오의금 | - |
dc.contributor.author | 추상희 | - |
dc.date.accessioned | 2014-12-18T08:22:34Z | - |
dc.date.available | 2014-12-18T08:22:34Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1099-8004 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86190 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study was to examine the effects of a 6-month therapeutic lifestyle modification (TLM) program on chemokines related to oxidative stress, inflammation, endothelial dysfunction, and arterial stiffness in subjects with metabolic syndrome (MetS). METHODS: The authors performed a randomized controlled trial, assigning 52 women (mean age 62.7 ± 9.0 years) with MetS to a TLM intervention group (n = 31) or a control group (n = 21). The authors provided the TLM intervention group with health screening, exercise, low-calorie diet, and health education and counseling for 6 months and instructed the control group to maintain their usual lifestyle behaviors. Outcome variables included levels of myeloperoxidase (MPO), oxidized low-density lipoprotein (LDL), adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1β, interleukin-6, tumor necrosis factor-alpha (TNF-α), CD40L, monocyte chemotactic protein-1 (MCP-1), retinol-binding protein 4 (RBP-4), endothelin-1, and brachial-ankle pulse wave velocity. The authors used generalized estimating equation (GEE) analyses to estimate the effects of the TLM program. RESULTS: After the 6-month TLM program, hs-CRP levels decreased significantly, and MCP-1 levels increased at a significantly slower rate in the TLM group than they did in the control group (all p < .05). CONCLUSION: These results indicate that a TLM program could be effective for improving patient inflammatory states and may also be effective in preventing cardiovascular complications in subjects with MetS. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BIOLOGICAL RESEARCH FOR NURSING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Therapeutic Lifestyle Modification Program Reduces Plasma Levels of the Chemokines CRP and MCP-1 in Subjects With Metabolic Syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Nursing (간호대학) | - |
dc.contributor.department | Dept. of Nursing Environment Systems (임상간호과학과) | - |
dc.contributor.googleauthor | Eui Geum Oh | - |
dc.contributor.googleauthor | So Youn Bang | - |
dc.contributor.googleauthor | Soo Hyun Kim | - |
dc.contributor.googleauthor | Sa Saeng Hyun | - |
dc.contributor.googleauthor | Sang Hui Chu | - |
dc.contributor.googleauthor | Justin Y. Jeon | - |
dc.contributor.googleauthor | Jee Aee Im | - |
dc.contributor.googleauthor | Jung Eun Lee | - |
dc.contributor.googleauthor | Mi Kyung Lee | - |
dc.identifier.doi | 10.1177/1099800411416637 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02393 | - |
dc.contributor.localId | A04232 | - |
dc.relation.journalcode | J00304 | - |
dc.identifier.eissn | 1552-4175 | - |
dc.identifier.pmid | metabolic syndrome ; lifestyle modification ; inflammation | - |
dc.identifier.url | http://brn.sagepub.com/content/15/1/48.long | - |
dc.subject.keyword | metabolic syndrome | - |
dc.subject.keyword | lifestyle modification | - |
dc.subject.keyword | inflammation | - |
dc.contributor.alternativeName | Oh, Eui Geum | - |
dc.contributor.alternativeName | Choo, Sang Hee | - |
dc.contributor.affiliatedAuthor | Oh, Eui Geum | - |
dc.contributor.affiliatedAuthor | Choo, Sang Hee | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 48 | - |
dc.citation.endPage | 55 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL RESEARCH FOR NURSING, Vol.15(1) : 48-55, 2013 | - |
dc.identifier.rimsid | 28840 | - |
dc.type.rims | ART | - |
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