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Therapeutic effects of water soluble danshen extracts on atherosclerosis

Authors
 Yoon Hee Cho ; Cheol Ryong Ku ; Eun Jig Lee ; MiRan Seo ; Hyun Chul Lee ; Mankil Jung ; Cheol Soon Lee ; Ae-Jung Kim ; Dongkyu Kim ; Dong Hoon Choi ; Eun Hee Kim ; Ji Hoe Heo ; Zhen-Yu Hong 
Citation
 Evidence-Based Complementary and Alternative Medicine, Vol.2013 : 623639, 2013 
Journal Title
 Evidence-Based Complementary and Alternative Medicine 
ISSN
 1741-427X 
Issue Date
2013
Abstract
Danshen is a traditional Chinese medicine with many beneficial effects on cardiovascular diseases. The aim of this study was to evaluate the mechanisms responsible for the antiatherogenic effect of water soluble Danshen extracts (DEs). Rat vascular smooth muscle cells (VSMCs) and human umbilical vein endothelial cells (HUVECs) were treated with DE. To evaluate the effects of DE in vivo, carotid balloon injury and tail vein thrombosis were induced in Sprague-Dawley (SD) rats and iliac artery stent was induced in New Zealand white rabbits. The inhibitory action of DE on platelet aggregation was confirmed with an impedance aggregometer. DE inhibited the production of reactive oxygen species, and the migration and proliferation of platelet-derived growth factor-BB stimulated VSMCs. Furthermore, DE prevented inflammation and apoptosis in HUVECs. Both effects of DE were reconfirmed in both rat models. DE treatment attenuated platelet aggregation in both in vivo and ex vivo conditions. Pretreatment with DE prevented tail vein thrombosis, which is normally induced by κ-carrageenan injection. Lastly, DE-treated rabbits showed decreased in-stent restenosis of stented iliac arteries. These results suggest that water soluble DE modulates key atherogenic events in VSMCs, endothelial cells, and platelets in both in vitro and in vivo conditions
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86145
DOI
10.1155/2013/623639
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
1. 연구논문 > 1. College of Medicine > Dept. of Neurology
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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