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Therapeutic effects of water soluble danshen extracts on atherosclerosis

Authors
 Yoon Hee Cho  ;  Cheol Ryong Ku  ;  Zhen-Yu Hong  ;  Ji Hoe Heo  ;  Eun Hee Kim  ;  Dong Hoon Choi  ;  Dongkyu Kim  ;  Ae-Jung Kim  ;  Cheol Soon Lee  ;  Mankil Jung  ;  Hyun Chul Lee  ;  MiRan Seo  ;  Eun Jig Lee 
Citation
 EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, Vol.2013 : 623639, 2013 
Journal Title
 EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 
ISSN
 1741-427X 
Issue Date
2013
Abstract
Danshen is a traditional Chinese medicine with many beneficial effects on cardiovascular diseases. The aim of this study was to evaluate the mechanisms responsible for the antiatherogenic effect of water soluble Danshen extracts (DEs). Rat vascular smooth muscle cells (VSMCs) and human umbilical vein endothelial cells (HUVECs) were treated with DE. To evaluate the effects of DE in vivo, carotid balloon injury and tail vein thrombosis were induced in Sprague-Dawley (SD) rats and iliac artery stent was induced in New Zealand white rabbits. The inhibitory action of DE on platelet aggregation was confirmed with an impedance aggregometer. DE inhibited the production of reactive oxygen species, and the migration and proliferation of platelet-derived growth factor-BB stimulated VSMCs. Furthermore, DE prevented inflammation and apoptosis in HUVECs. Both effects of DE were reconfirmed in both rat models. DE treatment attenuated platelet aggregation in both in vivo and ex vivo conditions. Pretreatment with DE prevented tail vein thrombosis, which is normally induced by κ-carrageenan injection. Lastly, DE-treated rabbits showed decreased in-stent restenosis of stented iliac arteries. These results suggest that water soluble DE modulates key atherogenic events in VSMCs, endothelial cells, and platelets in both in vitro and in vivo conditions
Files in This Item:
T201300090.pdf Download
DOI
10.1155/2013/623639
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Cheol Ryong(구철룡) ORCID logo https://orcid.org/0000-0001-8693-9630
Kim, Dong Kyu(김동규)
Kim, Eun Hee(김은희)
Seo, Mi Ran(서미란)
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Lee, Hyun Chul(이현철)
Cho, Yoon Hee(조윤희)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
Hong, Zhen-Yu(홍진우)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86145
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