Cited 21 times in
Therapeutic effects of water soluble danshen extracts on atherosclerosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구철룡 | - |
dc.contributor.author | 김동규 | - |
dc.contributor.author | 김은희 | - |
dc.contributor.author | 서미란 | - |
dc.contributor.author | 이은직 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 조윤희 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 허지회 | - |
dc.contributor.author | 홍진우 | - |
dc.contributor.author | Ku, Cheol Ryong | - |
dc.contributor.author | Kim, Dong Kyu | - |
dc.contributor.author | Seo, Mi Ran | - |
dc.contributor.author | Lee, Eun Jig | - |
dc.contributor.author | Lee, Hyun Chul | - |
dc.contributor.author | Choi, Dong Hoon | - |
dc.contributor.author | Heo, Ji Hoe | - |
dc.contributor.author | Hong, Zhen-Yu | - |
dc.contributor.author | Cho, Yoon Hee | - |
dc.contributor.author | Kim, Eun Hee | - |
dc.date.accessioned | 2014-12-18T08:21:06Z | - |
dc.date.available | 2014-12-18T08:21:06Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86145 | - |
dc.description.abstract | Danshen is a traditional Chinese medicine with many beneficial effects on cardiovascular diseases. The aim of this study was to evaluate the mechanisms responsible for the antiatherogenic effect of water soluble Danshen extracts (DEs). Rat vascular smooth muscle cells (VSMCs) and human umbilical vein endothelial cells (HUVECs) were treated with DE. To evaluate the effects of DE in vivo, carotid balloon injury and tail vein thrombosis were induced in Sprague-Dawley (SD) rats and iliac artery stent was induced in New Zealand white rabbits. The inhibitory action of DE on platelet aggregation was confirmed with an impedance aggregometer. DE inhibited the production of reactive oxygen species, and the migration and proliferation of platelet-derived growth factor-BB stimulated VSMCs. Furthermore, DE prevented inflammation and apoptosis in HUVECs. Both effects of DE were reconfirmed in both rat models. DE treatment attenuated platelet aggregation in both in vivo and ex vivo conditions. Pretreatment with DE prevented tail vein thrombosis, which is normally induced by κ-carrageenan injection. Lastly, DE-treated rabbits showed decreased in-stent restenosis of stented iliac arteries. These results suggest that water soluble DE modulates key atherogenic events in VSMCs, endothelial cells, and platelets in both in vitro and in vivo conditions | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Therapeutic effects of water soluble danshen extracts on atherosclerosis | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) | - |
dc.contributor.googleauthor | Yoon Hee Cho | - |
dc.contributor.googleauthor | Cheol Ryong Ku | - |
dc.contributor.googleauthor | Zhen-Yu Hong | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.contributor.googleauthor | Eun Hee Kim | - |
dc.contributor.googleauthor | Dong Hoon Choi | - |
dc.contributor.googleauthor | Dongkyu Kim | - |
dc.contributor.googleauthor | Ae-Jung Kim | - |
dc.contributor.googleauthor | Cheol Soon Lee | - |
dc.contributor.googleauthor | Mankil Jung | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | MiRan Seo | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.identifier.doi | 10.1155/2013/623639 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01876 | - |
dc.contributor.localId | A00201 | - |
dc.contributor.localId | A00397 | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04369 | - |
dc.contributor.localId | A04443 | - |
dc.contributor.localId | A03876 | - |
dc.contributor.localId | A00830 | - |
dc.relation.journalcode | J00856 | - |
dc.identifier.eissn | 1741-4288 | - |
dc.identifier.pmid | 23401716 | - |
dc.contributor.alternativeName | Ku, Cheol Ryong | - |
dc.contributor.alternativeName | Kim, Dong Kyu | - |
dc.contributor.alternativeName | Kim, Eun Hee | - |
dc.contributor.alternativeName | Seo, Mi Ran | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cho, Yoon Hee | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.alternativeName | Hong, Zhen Yu | - |
dc.contributor.affiliatedAuthor | Seo, Mi Ran | - |
dc.contributor.affiliatedAuthor | Ku, Cheol Ryong | - |
dc.contributor.affiliatedAuthor | Kim, Dong Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Hong, Zhen-Yu | - |
dc.contributor.affiliatedAuthor | Cho, Yoon Hee | - |
dc.contributor.affiliatedAuthor | Kim, Eun Hee | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 2013 | - |
dc.citation.startPage | 623639 | - |
dc.identifier.bibliographicCitation | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, Vol.2013 : 623639, 2013 | - |
dc.identifier.rimsid | 28810 | - |
dc.type.rims | ART | - |
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