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Magnetic nanocomplexes and the physiological challenges associated with their use for cancer imaging and therapy

Authors
 Eunjung Kim  ;  Kwangyeol Lee  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 Journal of Materials Chemistry B, Vol.1(6) : 729-739, 2013 
Journal Title
 Journal of Materials Chemistry B 
ISSN
 2050-750X 
Issue Date
2013
Abstract
Magnetic nanoparticles offer potential advances in cancer treatment. One example is cancer theranostics, which refers to the combination of a diagnostic tool, i.e., magnetic resonance (MR) imaging, and therapeutic entities such as drugs, oligonucleotides, antibodies, and peptides. They can be conjugated with bioactive molecules and have the ability to form a magnetic field gradient under an external magnetic field. They can offer a variety of active drug delivery and imaging strategies along with modalities such as magnetic hyperthermia. Imaging with magnetic nanoparticles can facilitate more effective cancer therapy through more well informed decision-making. In this article, we review notable progress in magnetic particle design, including surface modifications and multi-functionalization, and we discuss the recent bioapplications of magnetic nanoparticles in simultaneous cancer imaging and therapy.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86140
DOI
10.1039/C2TB00294A
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
허용민(Huh, Yong Min)
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Full Text
http://pubs.rsc.org/en/Content/ArticleLanding/2013/TB/C2TB00294A#!divAbstract
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