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Multiregional single-cell transcriptomics reveals an association between partial EMT and immunosuppressive states in oral squamous cell carcinoma

Authors
 Seunghoon Kim  ;  Hyun Jung Kee  ;  Dahee Kim  ;  Jinho Jang  ;  Hyoung-Oh Jeong  ;  Nam Suk Sim  ;  Mischa Selig  ;  Jana Ihlow  ;  Livius Penter  ;  Taejoo Hwang  ;  David Whee-Young Choi  ;  Kyoung Jun Lee  ;  Jaewoong Lee  ;  Young Min Park  ;  Semin Lee  ;  Yoon Woo Koh 
Citation
 ISCIENCE, Vol.28(9) : 112988, 2025-09 
Journal Title
ISCIENCE
Issue Date
2025-09
MeSH
0
Abstract
Microenvironment
Article Number
 10.1016/j.isci.2025.112988 
DOI
Oral squamous cell carcinoma (OSCC) is highly heterogeneous and metastatic, and the mechanisms driving OSCC development, progression, and metastasis remain elusive. Here, we performed single-cell RNA sequencing on 231,442 cells obtained from the tumor core (TC), tumor periphery (TP), adjacent surrounding tissue (ST), and metastatic lymph node (mLN) samples of 10 patients with human papillomavirus (HPV)-negative OSCC. TP and TC showed no major immune cell phenotype differences. Interestingly, partial EMT (p-EMT) cells showed significant activation of glycolysis and hypoxia signatures, serving as potential biomarkers for clinical outcomes. Moreover, p-EMT scores of epithelial cells positively correlated with M2 scores of tumor-associated macrophages, while the proportion of p-EMT at TP was negatively associated with that of GZMB + exhausted CD8+ T cells with cytotoxic potential and TNFRSF9 + mast cells, conferring an adverse prognosis. Our study provides insights into understanding the interplay between intratumoral heterogeneity and the tumor microenvironment of advanced HPV-negative OSCC.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Koh, Yoon Woo(고윤우)
Kee, Hyun Jung(기현정) ORCID logo https://orcid.org/0000-0003-4350-1852
Kim, Da Hee(김다희) ORCID logo https://orcid.org/0000-0001-7286-1334
Park, Young Min(박영민) ORCID logo https://orcid.org/0000-0002-7593-8461
Sim, Nam Suk(심남석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/207550
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