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Multiregional single-cell transcriptomics reveals an association between partial EMT and immunosuppressive states in oral squamous cell carcinoma

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dc.contributor.author고윤우-
dc.contributor.author기현정-
dc.contributor.author김다희-
dc.contributor.author박영민-
dc.contributor.author심남석-
dc.date.accessioned2025-10-15T02:01:42Z-
dc.date.available2025-10-15T02:01:42Z-
dc.date.issued2025-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/207550-
dc.description.abstractMicroenvironment-
dc.description.statementOfResponsibilityT202506284.pdf-
dc.languageEnglish-
dc.publisherCell Press-
dc.relation.isPartOfISCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESH0-
dc.titleMultiregional single-cell transcriptomics reveals an association between partial EMT and immunosuppressive states in oral squamous cell carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.googleauthorSeunghoon Kim-
dc.contributor.googleauthorHyun Jung Kee-
dc.contributor.googleauthorDahee Kim-
dc.contributor.googleauthorJinho Jang-
dc.contributor.googleauthorHyoung-Oh Jeong-
dc.contributor.googleauthorNam Suk Sim-
dc.contributor.googleauthorMischa Selig-
dc.contributor.googleauthorJana Ihlow-
dc.contributor.googleauthorLivius Penter-
dc.contributor.googleauthorTaejoo Hwang-
dc.contributor.googleauthorDavid Whee-Young Choi-
dc.contributor.googleauthorKyoung Jun Lee-
dc.contributor.googleauthorJaewoong Lee-
dc.contributor.googleauthorYoung Min Park-
dc.contributor.googleauthorSemin Lee-
dc.contributor.googleauthorYoon Woo Koh-
dc.identifier.doiOral squamous cell carcinoma (OSCC) is highly heterogeneous and metastatic, and the mechanisms driving OSCC development, progression, and metastasis remain elusive. Here, we performed single-cell RNA sequencing on 231,442 cells obtained from the tumor core (TC), tumor periphery (TP), adjacent surrounding tissue (ST), and metastatic lymph node (mLN) samples of 10 patients with human papillomavirus (HPV)-negative OSCC. TP and TC showed no major immune cell phenotype differences. Interestingly, partial EMT (p-EMT) cells showed significant activation of glycolysis and hypoxia signatures, serving as potential biomarkers for clinical outcomes. Moreover, p-EMT scores of epithelial cells positively correlated with M2 scores of tumor-associated macrophages, while the proportion of p-EMT at TP was negatively associated with that of GZMB + exhausted CD8+ T cells with cytotoxic potential and TNFRSF9 + mast cells, conferring an adverse prognosis. Our study provides insights into understanding the interplay between intratumoral heterogeneity and the tumor microenvironment of advanced HPV-negative OSCC.-
dc.contributor.localIdA00133-
dc.contributor.localIdA00279-
dc.contributor.localIdA04831-
dc.contributor.localIdA01566-
dc.contributor.localIdA06297-
dc.relation.journalcodeJ03874-
dc.identifier.eissn2589-0042-
dc.identifier.pmid41054545-
dc.contributor.alternativeNameKoh, Yoon Woo-
dc.contributor.affiliatedAuthor고윤우-
dc.contributor.affiliatedAuthor기현정-
dc.contributor.affiliatedAuthor김다희-
dc.contributor.affiliatedAuthor박영민-
dc.contributor.affiliatedAuthor심남석-
dc.citation.volume28-
dc.citation.number9-
dc.citation.startPage112988-
dc.identifier.bibliographicCitationISCIENCE, Vol.28(9) : 112988, 2025-09-
dc.identifier.articleno10.1016/j.isci.2025.112988-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
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