Radiotranscriptomics in papillary thyroid carcinoma complement current noninvasive risk stratification system

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Authors: Dong Hyun Seo ; Eunjung Lee ; Jung Hyun Yoon ; Eun Gyeong Park ; Sunmi Park ; Hwa Young Lee ; Joon Ho ; Cho Rok Lee ; Kyunghwa Han ; Jandee Lee ; Jin Young Kwak ; Young Suk Jo

Keywords: Adult ; Aged ; Female ; Gene Expression Profiling ; Humans ; Male ; Middle Aged ; Prognosis ; Risk Assessment ; Thyroid Cancer, Papillary* / diagnosis ; Thyroid Cancer, Papillary* / diagnostic imaging ; Thyroid Cancer, Papillary* / genetics ; Thyroid Cancer, Papillary* / pathology ; Thyroid Neoplasms* / diagnostic imaging ; Thyroid Neoplasms* / genetics ; Thyroid Neoplasms* / pathology ; Transcriptome*

DOI: Papillary thyroid carcinoma (PTC) generally has a favorable prognosis; however, overtreatment persists because of the lack of reliable noninvasive risk stratification tools. This study developed a radiomics-based approach to enhance the preoperative assessment of PTC. Imaging features from 255 patients were analyzed, and three tumor clusters were identified via unsupervised clustering, with one cluster (Cluster 2) displaying favorable clinical and molecular profiles. A radiomics score was constructed and validated internally and externally, achieving high diagnostic accuracy (area under the curve of 0.98) and independently predicting benign features such as a lower N stage and favorable treatment responses. Transcriptomic analysis revealed immune activation and survival-related gene expression in Cluster 2. The model demonstrated robust performance in stratifying patients for active surveillance and may complement current diagnostic frameworks, offering a precise, noninvasive tool to guide clinical decision-making.

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

Yonsei Authors: Kwak, Jin Young(곽진영) https://orcid.org/0000-0002-6212-1495
Park, Sunmi(박선미)
Yoon, Jung Hyun(윤정현) https://orcid.org/0000-0002-2100-3513
Lee, Jan Dee(이잔디) https://orcid.org/0000-0003-4090-0049
Lee, Cho Rok(이초록) https://orcid.org/0000-0001-7848-3709
Jo, Young Suk(조영석) https://orcid.org/0000-0001-9926-8389
Han, Kyung Hwa(한경화)
Ho, Joon(허준) https://orcid.org/0000-0001-9782-0432

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