One-carbon metabolic pathway is a novel molecular signature for CD44-positive intestinal-type gastric cancer

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Authors: Seyeon Joo ; Yoojin Bae ; Bo Kyung Yoon ; Yeonjin Je ; Yuna Kim ; Minki Kim ; Su-Jin Shin ; Sungsoon Fang ; Jie-Hyun Kim

DOI: Intratumoral heterogeneity (ITH), arising from various factors, plays a crucial role in diverse cancers, yet research on ITH remains in its early stages. To explore this phenomenon further, we conducted single-nuclei transcriptome profiling on patient-derived organoids (PDOs) from two histologically pure subtypes of gastric cancer. We identified differences in cancer stem cell marker expression among intestinal-type samples and their correlation with one-carbon (1C) metabolism. Notably, some gastric cancer samples, although histologically classified as intestinal-type, exhibited diffuse-like genetic characteristics. This finding suggests the potential for employing a 1C metabolism inhibition strategy as a therapeutic approach for these genetically diffuse-like gastric cancers. This study highlights the necessity of addressing ITH in PDO-based preclinical models and contributes valuable insights toward advancing precision medicine treatments for gastric cancer.

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

Yonsei Authors: Kim, Yuna(김윤아)
Kim, Jie-Hyun(김지현) https://orcid.org/0000-0002-9198-3326
Shin, Su Jin(신수진) https://orcid.org/0000-0001-9114-8438
Yoon, Bo Kyung(윤보경)
Fang, Sungsoon(황성순) https://orcid.org/0000-0003-0201-5567

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YUHSpace: One-carbon metabolic pathway is a novel molecular signature for CD44-positive intestinal-type gastric cancer