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One-carbon metabolic pathway is a novel molecular signature for CD44-positive intestinal-type gastric cancer

DC Field Value Language
dc.contributor.author김윤아-
dc.contributor.author김지현-
dc.contributor.author신수진-
dc.contributor.author윤보경-
dc.contributor.author황성순-
dc.date.accessioned2025-10-15T01:39:55Z-
dc.date.available2025-10-15T01:39:55Z-
dc.date.issued2025-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/207434-
dc.description.statementOfResponsibilityT202505907.pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfCELL DEATH DISCOVERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESH0-
dc.titleOne-carbon metabolic pathway is a novel molecular signature for CD44-positive intestinal-type gastric cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSeyeon Joo-
dc.contributor.googleauthorYoojin Bae-
dc.contributor.googleauthorBo Kyung Yoon-
dc.contributor.googleauthorYeonjin Je-
dc.contributor.googleauthorYuna Kim-
dc.contributor.googleauthorMinki Kim-
dc.contributor.googleauthorSu-Jin Shin-
dc.contributor.googleauthorSungsoon Fang-
dc.contributor.googleauthorJie-Hyun Kim-
dc.identifier.doiIntratumoral heterogeneity (ITH), arising from various factors, plays a crucial role in diverse cancers, yet research on ITH remains in its early stages. To explore this phenomenon further, we conducted single-nuclei transcriptome profiling on patient-derived organoids (PDOs) from two histologically pure subtypes of gastric cancer. We identified differences in cancer stem cell marker expression among intestinal-type samples and their correlation with one-carbon (1C) metabolism. Notably, some gastric cancer samples, although histologically classified as intestinal-type, exhibited diffuse-like genetic characteristics. This finding suggests the potential for employing a 1C metabolism inhibition strategy as a therapeutic approach for these genetically diffuse-like gastric cancers. This study highlights the necessity of addressing ITH in PDO-based preclinical models and contributes valuable insights toward advancing precision medicine treatments for gastric cancer.-
dc.contributor.localIdA06043-
dc.contributor.localIdA00996-
dc.contributor.localIdA04596-
dc.contributor.localIdA05928-
dc.contributor.localIdA05443-
dc.relation.journalcodeJ03612-
dc.identifier.eissn2058-7716-
dc.identifier.pmid40849307-
dc.contributor.alternativeNameKim, Yuna-
dc.contributor.affiliatedAuthor김윤아-
dc.contributor.affiliatedAuthor김지현-
dc.contributor.affiliatedAuthor신수진-
dc.contributor.affiliatedAuthor윤보경-
dc.contributor.affiliatedAuthor황성순-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage399-
dc.identifier.bibliographicCitationCELL DEATH DISCOVERY, Vol.11(1) : 399, 2025-08-
dc.identifier.articleno10.1038/s41420-025-02704-5-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
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