조혈모세포이식 환자의 지지중재에 대한 통합적 문헌고찰

Abstract

Purpose: This study aimed to summarize supportive care interventions for patients undergoing hematopoietic stem cell transplan tation. Methods: An integrative review using Whittemore and Knafl’s method was implemented. Additionally, a literature inquiry was conducted across PubMed, CINAHL, EMBASE, RISS, KISS, and NDSL for studies published between 2014 and 2024, using keywords such as “hematopoietic stem cell transplantation (HSCT),” “intervention,” “supportive care,” and “program.” Results:Thirteen studies matched the criteria, and their quality was assessed using the Risk of Bias Assessment Tool for Non-ran domized Studies (RoBANS), revealing a generally low risk of bias. Most studies included both allogeneic and autologous HSCT pa tients, were conducted in single research centers, and had randomized controlled trial designs. The interventions frequently involved nurse-led support, with sessions lasting at least 60 minutes, often conducted daily. Commonly measured outcome variables included quality of life, fatigue, anxiety, depression, and physical functioning. Many interventions combined at least two types of support– such as physical, emotional, or informational–demonstrating the diverse composition of supportive care interventions. Conclusion: The findings highlight the necessity of comprehensive supportive care interventions integrating physical, emotional, and informa tional support for HSCT patients. Multidisciplinary, standardized supportive care interventions are necessary. Therefore, future studies should explore long-term efficacy and tailored programs.