Application of a quality threshold to improve liver shear wave elastography measurements in free-breathing pediatric patients

Abstract

Purpose: This study assessed the benefits of quality threshold (QT) implementation for liver shear wave elastography (SWE) in children during free breathing. Methods: The QT, which adjusts the SWE map display based on shear wave quality, was set at 55%. Phantom measurements (PMs) were taken with a fixed probe using QT (termed PM-1); a moving probe without QT (PM-2); and a moving probe with QT (PM-3). Each measurement was subjected to random samplings of various sizes. Clinical measurements (CMs) were obtained from children with biliary atresia using following protocols: CM-1, manually defined regions of interest (ROIs); CM-2, default ROIs without QT; and CM-3, default ROIs with QT. Elasticity measurements were compared across fibrosis grades, and color patterns on the SWE maps were analyzed. Results: In the phantom experiments, the moving probe produced lower elasticity measurements; this difference decreased upon QT application. With the moving probe, random sampling indicated fewer interquartile range-to-median ratios exceeding 30% upon QT application (4% vs. 14% when five values were sampled, P=0.004). In clinical experiments, QT improved the differentiation of fibrosis grade in patients over 5 years old, with a significant difference between moderate and severe fibrosis (P=0.004). Elasticity variability was positively correlated with fibrosis grade (tau=0.376, tau=0.376, P<0.001). Certain apparent errors, termed artificial stripe patterns, were not eliminated by QT. Conclusion: Applying QT to exclude low-quality pixels can minimize measurement error and improve differentiation of liver fibrosis grades. The presence of an artificial stripe pattern on the SWE indicate exclusion.