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Polystyrene microplastics induce activation and cell death of neutrophils through strong adherence and engulfment

Authors
 Koung-Min Park  ;  Bora Kim  ;  Wonjin Woo  ;  Lark Kyun Kim  ;  Young-Min Hyun 
Citation
 JOURNAL OF HAZARDOUS MATERIALS, Vol.480 : 136100, 2024-12 
Journal Title
JOURNAL OF HAZARDOUS MATERIALS
ISSN
 0304-3894 
Issue Date
2024-12
Keywords
Cell death ; Cell migration ; Inflammation ; Microplastics ; Neutrophil
Abstract
Ingested microplastics (MPs) can accumulate throughout whole body, which may induce the dysfunction of immune system. However, it remains unclear how MP exposure affects innate immune responses at the cellular level. We found that mouse neutrophils strongly bind and then engulf polystyrene MPs. This interaction leads to proinflammatory state of neutrophils and eventually results in apoptotic cell death through toll-like receptor signaling pathway in a bacteria-recognition mimetic manner. Moreover, our data verified that orally administered polystyrene MPs reach various organs in mice, where they are interacted with and endocytosed by neutrophils. We confirmed that human neutrophils also strongly bind and internalize polystyrene MPs. Additionally, RNA sequencing analysis of polystyrene MPs-exposed human neutrophils showed the upregulation of cell death-related function. Therefore, the accumulated MPs may exacerbate inflammatory immune response by disrupting neutrophil function. These results provide novel insight into the adverse responses of neutrophils induced by MP exposure.
Files in This Item:
T202406755.pdf Download
DOI
10.1016/j.jhazmat.2024.136100
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Lark Kyun(김락균) ORCID logo https://orcid.org/0000-0001-5983-4470
Kim, Bora(김보라) ORCID logo https://orcid.org/0000-0003-2783-3806
Hyun, Young-Min(현영민) ORCID logo https://orcid.org/0000-0002-0567-2039
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/201216
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