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A human brain atlas of χ-separation for normative iron and myelin distributions

Authors
 Kyeongseon Min  ;  Beomseok Sohn  ;  Woo Jung Kim  ;  Chae Jung Park  ;  Soohwa Song  ;  Dong Hoon Shin  ;  Kyung Won Chang  ;  Na-Young Shin  ;  Minjun Kim  ;  Hyeong-Geol Shin  ;  Phil Hyu Lee  ;  Jongho Lee 
Citation
 NMR IN BIOMEDICINE, Vol.37(12) : e5226, 2024-12 
Journal Title
NMR IN BIOMEDICINE
ISSN
 0952-3480 
Issue Date
2024-12
MeSH
Adolescent ; Adult ; Aged ; Atlases as Topic ; Brain* / diagnostic imaging ; Brain* / metabolism ; Female ; Humans ; Iron* / metabolism ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Myelin Sheath* / metabolism ; Young Adult
Keywords
chi‐separation atlas ; iron imaging ; myelin imaging ; quantitative susceptibility mapping ; susceptibility source separation ; x‐separation atlas
Abstract
Iron and myelin are primary susceptibility sources in the human brain. These substances are essential for a healthy brain, and their abnormalities are often related to various neurological disorders. Recently, an advanced susceptibility mapping technique, which is referred to as χ-separation (pronounced as "chi"-separation), has been proposed, successfully disentangling paramagnetic iron from diamagnetic myelin. This method provided a new opportunity for generating high-resolution iron and myelin maps of the brain. Utilizing this technique, this study constructs a normative χ-separation atlas from 106 healthy human brains. The resulting atlas provides detailed anatomical structures associated with the distributions of iron and myelin, clearly delineating subcortical nuclei, thalamic nuclei, and white matter fiber bundles. Additionally, susceptibility values in a number of regions of interest are reported along with age-dependent changes. This atlas may have direct applications such as localization of subcortical structures for deep brain stimulation or high-intensity focused ultrasound and also serve as a valuable resource for future research.
Full Text
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/nbm.5226
DOI
10.1002/nbm.5226
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Woo Jung(김우정) ORCID logo https://orcid.org/0000-0002-4963-4819
Park, Chae Jung(박채정) ORCID logo https://orcid.org/0000-0002-5567-8658
Shin, Na Young(신나영)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chang, Kyung Won(장경원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/201135
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