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De novo versus recurrent metastatic breast cancer affects the extent of brain metastases

Authors
 Bio Joo  ;  Jee Hung Kim  ;  Sung Gwe Ahn  ;  Mina Park  ;  Sang Hyun Suh  ;  Sung Jun Ahn 
Citation
 JOURNAL OF NEURO-ONCOLOGY, Vol.169(2) : 309-316, 2024-09 
Journal Title
JOURNAL OF NEURO-ONCOLOGY
ISSN
 0167-594X 
Issue Date
2024-09
MeSH
Adult ; Aged ; Brain Neoplasms* / secondary ; Breast Neoplasms* / pathology ; Female ; Humans ; Middle Aged ; Neoplasm Recurrence, Local* / pathology ; Retrospective Studies
Keywords
Brain metastasis ; Breast cancer ; De novo metastatic breast cancer ; Oligometastasis ; Recurrent metastatic breast cancer
Abstract
PurposeWe aimed to identify factors associated with the extent of brain metastases in patients with breast cancer to help distinguish brain oligometastases (1-4 brain metastases) from extensive metastases (5 or more brain metastases).MethodsThis retrospective observational study included 100 female patients diagnosed with brain metastases from breast cancer at a single institution between January 2011 and April 2022. Patient demographics and tumor characteristics were compared between the brain oligometastases group and the extensive metastases group. Multivariable logistic regression analysis was performed to determine the independent factors, including age at initial diagnosis, initial stage, breast cancer subtype, detection time of brain metastases, and de novo or recurrent status of the metastatic disease. In a subgroup analysis of patients with brain oligometastases, demographic and tumor characteristics were compared between patients with single and two-four brain metastases.ResultsOf the 100 patients, 56 had brain oligometastases, while 44 had extensive brain metastases. The multivariable logistic regression analysis revealed that only the de novo/recurrent status of metastatic breast cancer was significantly associated with the extent of brain metastasis (p = 0.023). In the subgroup analysis of 56 patients with brain oligometastases, those diagnosed at an earlier stage were more likely to have a single brain metastasis (p = 0.008).ConclusionPatients with de novo metastatic breast cancer are more likely to develop extensive brain metastases than those with recurrent metastatic breast cancer. This insight could influence the development of tailored approaches for monitoring and treating brain metastases, supporting the potential advantages of routine brain screening for patients newly diagnosed with stage IV breast cancer.
Full Text
https://link.springer.com/article/10.1007/s11060-024-04735-x
DOI
10.1007/s11060-024-04735-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jee Hung(김지형) ORCID logo https://orcid.org/0000-0002-9044-8540
Park, Mina(박미나) ORCID logo https://orcid.org/0000-0002-2005-7560
Suh, Sang Hyun(서상현) ORCID logo https://orcid.org/0000-0002-7098-4901
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Ahn, Sung Jun(안성준) ORCID logo https://orcid.org/0000-0003-0075-2432
Joo, Bio(주비오) ORCID logo https://orcid.org/0000-0001-7460-1421
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/201007
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