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Malnutrition is associated with mortality in Sjögren's syndrome-associated interstitial lung disease

Authors
 Eunki Chung  ;  Ala Woo  ;  Seung Hyun Yong  ;  Youngmok Park  ;  Sang Hoon Lee  ;  Song Yee Kim  ;  Eun Young Kim  ;  Ji Ye Jung  ;  Young Ae Kang  ;  Young Sam Kim  ;  Moo Suk Park 
Citation
 SCIENTIFIC REPORTS, Vol.14(1) : 17842, 2024-12 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2024-12
MeSH
Aged ; Body Mass Index ; Female ; Humans ; Kaplan-Meier Estimate ; Lung Diseases, Interstitial* / complications ; Lung Diseases, Interstitial* / mortality ; Male ; Malnutrition* / complications ; Malnutrition* / mortality ; Middle Aged ; Nutrition Assessment ; Nutritional Status ; Prognosis ; Proportional Hazards Models ; ROC Curve ; Retrospective Studies ; Sjogren's Syndrome* / complications ; Sjogren's Syndrome* / mortality
Abstract
The role of nutritional status as a prognostic factor in patients with Sjögren’s syndrome-associated interstitial lung disease (SjS-ILD) is currently unclear. This study aimed to predict the prognosis of patients with SjS-ILD through their nutritional status assessment. In this retrospective observational study, nutritional status was evaluated at the time of diagnosis using body mass index (BMI) and nutritional markers such as controlling nutritional status (CONUT), the Glasgow prognostic score (GPS), and prognostic nutrition index (PNI) for all participants. Receiver operating characteristic (ROC) analyses were performed using BMI and each nutritional marker data to compare the area under the ROC curve (AUC) and find the cutoff value using the maximum Youden index. Kaplan–Meier analysis and Cox proportional hazards regression analysis were performed to predict the prognosis of SjS-ILD patients. A total of 112 SjS-ILD patients were enrolled in the study, and 8.9% died during the follow-up period. The median time from diagnosis to follow-up period was 4.2 years. The AUC for PNI was the highest among nutritional markers and BMI, and PNI cutoff value was used to distinguish between the PNI < 47.7 and PNI ≥ 47.7 groups. A statistical difference was observed in the Kaplan–Meier analysis and log-rank test (p = 0.005). In multivariable analyses, PNI < 47.7 (hazard ratio 9.40, 95% confidence interval 1.54–57.21) is associated with increased mortality, suggesting the importance of early nutritional intervention for malnutrition in SjS-ILD patients.
Files in This Item:
T202404982.pdf Download
DOI
39090289
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Song Yee(김송이) ORCID logo https://orcid.org/0000-0001-8627-486X
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Eun Young(김은영) ORCID logo https://orcid.org/0000-0002-3281-5744
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Park, Youngmok(박영목) ORCID logo https://orcid.org/0000-0002-5669-1491
Yong, Seung Hyun(용승현)
Woo, Ala(우아라)
Lee, Sang Hoon(이상훈) ORCID logo https://orcid.org/0000-0002-7706-5318
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200425
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