Cited 2 times in

Revisiting prognostic factors of gliomatosis cerebri in adult-type diffuse gliomas

Authors
 Ilah Shin  ;  Yongsik Sim  ;  Seo Hee Choi  ;  Yae Won Park  ;  Narae Lee  ;  Sung Soo Ahn  ;  Jong Hee Chang  ;  Se Hoon Kim  ;  Seung-Koo Lee 
Citation
 JOURNAL OF NEURO-ONCOLOGY, Vol.168(2) : 239-247, 2024-06 
Journal Title
JOURNAL OF NEURO-ONCOLOGY
ISSN
 0167-594X 
Issue Date
2024-06
MeSH
Adult ; Aged ; Brain Neoplasms* / diagnosis ; Brain Neoplasms* / genetics ; Brain Neoplasms* / mortality ; Brain Neoplasms* / pathology ; Brain Neoplasms* / surgery ; Female ; Follow-Up Studies ; Glioma / diagnosis ; Glioma / genetics ; Glioma / mortality ; Glioma / pathology ; Glioma / surgery ; Humans ; Isocitrate Dehydrogenase* / genetics ; Male ; Middle Aged ; Mutation ; Neoplasms, Neuroepithelial* / genetics ; Neoplasms, Neuroepithelial* / mortality ; Neoplasms, Neuroepithelial* / pathology ; Prognosis ; Retrospective Studies ; Survival Rate ; Young Adult
Keywords
Glioma ; Gliomatosis cerebri ; Magnetic resonance imaging ; Survival ; World Health Organization
Abstract
Purpose: There is lack of comprehensive analysis evaluating the impact of clinical, molecular, imaging, and surgical data on survival of patients with gliomatosis cerebri (GC). This study aimed to investigate prognostic factors of GC in adult-type diffuse glioma patients.

Methods: Retrospective chart and imaging review was performed in 99 GC patients from adult-type diffuse glioma (among 1,211 patients; 6 oligodendroglioma, 16 IDH-mutant astrocytoma, and 77 IDH-wildtype glioblastoma) from a single institution between 2005 and 2021. Predictors of overall survival (OS) of entire patients and IDH-wildtype glioblastoma patients were determined.

Results: The median OS was 16.7 months (95% confidence interval [CI] 14.2-22.2) in entire patients and 14.3 months (95% CI 12.2-61.9) in IDH-wildtype glioblastoma patients. In entire patients, KPS (hazard ratio [HR] = 0.98, P = 0.004), no 1p/19q codeletion (HR = 10.75, P = 0.019), MGMTp methylation (HR = 0.54, P = 0.028), and hemorrhage (HR = 3.45, P = 0.001) were independent prognostic factors on multivariable analysis. In IDH-wildtype glioblastoma patients, KPS (HR = 2.24, P = 0.075) was the only independent prognostic factor on multivariable analysis. In subgroup of IDH-wildtype glioblastoma with CE tumors, total resection of CE tumor did not remain as a significant prognostic factor (HR = 1.13, P = 0.685).

Conclusions: The prognosis of GC patients is determined by its underlying molecular type and patient performance status. Compared with diffuse glioma without GC, aggressive surgery of CE tumor in GC patients does not improve survival.
Full Text
https://link.springer.com/article/10.1007/s11060-024-04656-9
DOI
10.1007/s11060-024-04656-9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Park, Yae Won(박예원) ORCID logo https://orcid.org/0000-0001-8907-5401
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-0503-5558
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Choi, Seo Hee(최서희) ORCID logo https://orcid.org/0000-0002-4083-6414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200193
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