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METS-IR and all-cause mortality in Korean over 60 years old: Korean genome and epidemiology study-health examinees (KoGES-HEXA) cohorts

Authors
 Ha Eun Ryu  ;  Dong Hyuk Jung  ;  Seok-Jae Heo  ;  Byoungjin Park  ;  Yong Jae Lee 
Citation
 FRONTIERS IN ENDOCRINOLOGY, Vol.15 : 1346158, 2024-03 
Journal Title
FRONTIERS IN ENDOCRINOLOGY
Issue Date
2024-03
MeSH
Adult ; Aged ; Cardiovascular Diseases* / complications ; Diabetes Mellitus, Type 2* / complications ; Diabetes Mellitus, Type 2* / epidemiology ; Humans ; Insulin ; Insulin Resistance* ; Metabolic Syndrome* / complications ; Metabolic Syndrome* / epidemiology ; Metabolic Syndrome* / genetics ; Middle Aged ; Neoplasms* / complications ; Neoplasms* / epidemiology ; Republic of Korea / epidemiology
Keywords
METS-IR ; aging ; cancer ; cardiovascular disease ; insulin resistance ; mortality
Abstract
Background: The metabolic score for insulin resistance index (METS-IR) is a novel non insulin-based marker that indicates the risk for metabolic syndrome and type 2 diabetes mellitus (T2DM). However, METS-IR has not been investigated in relation to all–cause mortality. We investigated the longitudinal effect of METS-IR on all–cause mortality in a significantly large cohort of Korean adults over 60 years old.



Methods: Data were assessed from 30,164 Korean participants over 60 years of age from the Korean Genome and Epidemiology Study-Health Examinees (KoGES-HEXA) cohort data, linked with the death certificate database of the National Statistical Office. The participants were grouped into three according to METS-IR tertiles. We used multivariate Cox proportional-hazard regression models to prospectively assess hazard ratios (HRs) for all-cause mortality with 95% confidence intervals (CIs) over an 11-year postbaseline period.



Results: During the mean 11.7 years of follow-up, 2,821 individuals expired. The HRs of mortality for METS-IR tertiles were 1.16 (95% CI, 1.01–1.34) in T3 after adjustment for metabolic parameters, but the T2 did not show statistical significance towards increases for incident mortality respectively. In subgroup analysis depending on the cause of mortality, higher METS-IR was associated with cancer mortality (HR, 1.23, 95% CI, 1.01–1.51) but not with cardiovascular mortality (HR, 1.14, 95% CI, 0.83–1.57) after adjustment for the same confounding variables.



Conclusion: The METS-IR may be a useful predictive marker for all-cause mortality and cancer mortality, but not for cardiovascular mortality in subjects over 60 years of age. This implies that early detection and intervention strategies for metabolic syndrome could potentially benefit this identified group.
Files in This Item:
T202403537.pdf Download
DOI
10.3389/fendo.2024.1346158
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Park, Byoungjin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200025
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