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Brain volume in Tanzanian children with sickle cell anaemia: A neuroimaging study

Authors
 Mboka Jacob  ;  Jamie M Kawadler  ;  Russell Murdoch  ;  Magda Ahmed  ;  Hilda Tutuba  ;  Upendo Masamu  ;  Karin Shmueli  ;  Dawn E Saunders  ;  Chris A Clark  ;  Jinna Kim  ;  Shifa Hamdule  ;  Julie Makani  ;  Hanne Stotesbury  ;  Fenella J Kirkham 
Citation
 BRITISH JOURNAL OF HAEMATOLOGY, Vol.201(1) : 114-124, 2023-04 
Journal Title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN
 0007-1048 
Issue Date
2023-04
MeSH
Anemia, Sickle Cell* / complications ; Anemia, Sickle Cell* / diagnostic imaging ; Anemia, Sickle Cell* / pathology ; Brain / diagnostic imaging ; Brain / pathology ; Child ; Humans ; Magnetic Resonance Imaging / methods ; Male ; Neuroimaging ; Stroke* ; Tanzania ; White Matter*
Keywords
brain volume ; magnetic resonance imaging ; sickle cell anaemia ; silent cerebral infarction ; vasculopathy
Abstract
Brain injury is a common complication of sickle cell anaemia (SCA). White matter (WM) and cortical and subcortical grey matter (GM), structures may have reduced volume in patients with SCA. This study focuses on whether silent cerebral infarction (SCI), vasculopathy or anaemia affects WM and regional GM volumes in children living in Africa. Children with SCA (n = 144; aged 5-20 years; 74 male) and sibling controls (n = 53; aged 5-17 years; 29 male) underwent magnetic resonance imaging. Effects of SCI (n = 37), vasculopathy (n = 15), and haemoglobin were assessed. Compared with controls, after adjusting for age, sex and intracranial volume, patients with SCA had smaller volumes for WM and cortical, subcortical and total GM, as well as bilateral cerebellar cortex, globus pallidus, amygdala and right thalamus. Left globus pallidus volume was further reduced in patients with vasculopathy. Putamen and hippocampus volumes were larger in patients with SCA without SCI or vasculopathy than in controls. Significant positive effects of haemoglobin on regional GM volumes were confined to the controls. Patients with SCA generally have reduced GM volumes compared with controls, although some subcortical regions may be spared. SCI and vasculopathy may affect the trajectory of change in subcortical GM and WM volume. Brain volume in non-SCA children may be vulnerable to contemporaneous anaemia.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/bjh.18503
DOI
10.1111/bjh.18503
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199597
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