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Transgelin-2, a novel cancer stem cell-related biomarker, is a diagnostic and therapeutic target for biliary tract cancer
- Authors
- Jung Hyun Jo ; Soo Been Park ; Joowon Chung ; Taeyun Oh ; Hee Seung Lee ; Moon Jae Chung ; Jeong Youp Park ; Seungmin Bang ; Seung Woo Park ; Dawoon E Jung ; Si Young Song
- Citation
- BMC CANCER, Vol.24(1) : 357, 2024-03
- Journal Title
- BMC CANCER
- Issue Date
- 2024-03
- MeSH
- Biliary Tract Neoplasms* / drug therapy ; Biliary Tract Neoplasms* / genetics ; Biomarkers, Tumor / genetics ; Biomarkers, Tumor / metabolism ; Cell Line, Tumor ; Humans ; Microfilament Proteins* / genetics ; Microfilament Proteins* / metabolism ; Muscle Proteins / genetics
- Keywords
- Biliary tract cancer ; Cancer stem cell ; Cancer-associated fibroblasts ; Therapy-resistance ; Transgelin-2
- Abstract
- Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for the low response to anti-cancer treatment and the high recurrence rate. This study investigated the role of Transgelin-2 (TAGLN2), overexpressed in CSC in BTC cells, and analyzed its expression in patient tissues and serum to identify potential new targets for BTC.
- Files in This Item:
- T202402431.pdf Download
- Appears in Collections:
- 1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
- Yonsei Authors
-
Park, Seung Woo(박승우)
https://orcid.org/0000-0001-8230-964X
Park, Jeong Youp(박정엽) https://orcid.org/0000-0003-0110-8606
Bang, Seungmin(방승민) https://orcid.org/0000-0001-5209-8351
Song, Si Young(송시영) https://orcid.org/0000-0002-1417-4314
Lee, Hee Seung(이희승) https://orcid.org/0000-0002-2825-3160
Jung, Dawoon E.(정다운)
Chung, Moon Jae(정문재) https://orcid.org/0000-0002-5920-8549
Jo, Jung Hyun(조중현) https://orcid.org/0000-0002-2641-8873
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