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Can medication-related osteonecrosis of the jaw be attributed to specific microorganisms through oral microbiota analyses? A preliminary study

Authors
 Heon-Young Kim  ;  Young-Soo Jung  ;  Wonse Park  ;  Yoon Jeong Choi  ;  Jun-Young Kim 
Citation
 BMC ORAL HEALTH, Vol.24(1) : 160, 2024-02 
Journal Title
BMC ORAL HEALTH
Issue Date
2024-02
MeSH
Aged ; Aged, 80 and over ; Bisphosphonate-Associated Osteonecrosis of the Jaw* / surgery ; Bone Density Conservation Agents* ; Diphosphonates ; Humans ; Microbiota* ; Periodontitis* / complications ; Prospective Studies
Keywords
Medication-related osteonecrosis of the jaw ; Metagenomics ; Microbiome ; Oral bacteria
Abstract
BackgroundMedication-related osteonecrosis of the jaw (MRONJ) can cause significant pain and loss of aesthetics and function if not treated properly. However, diagnosis still relies on detailed intraoral examinations and imaging. Prognosis varies even among patients with similar stages or conditions of MRONJ, emphasizing the need for a deeper understanding of its complex mechanisms. Thus, this study aimed to identify the oral microbiota of patients with MRONJ.MethodsThis single-center prospective cohort study included patients with confirmed MRONJ who visited the Department of Oral and Maxillofacial Surgery at Yonsei University Dental Hospital between 2021 and 2022. Oral swab samples were collected from the affected and unaffected sides of each patient. The composition and enumeration of the microbial communities were analyzed, and the diversity was compared to verify ecological changes in the groups using a next-generation sequencing-based 16S metagenomic analysis. A statistical analysis was performed using Wilcoxon signed-rank test with SPSS version 22, and values of P less than 0.05 were considered statistically significant.ResultsThe final study sample included 12 patients. The mean age was 82.67 +/- 5.73 (range, 72-90) years. Changes in microbial composition were observed at different taxonomic levels (phylum, genus, and species). The identified microorganisms were commonly associated with periodontitis, gingival disease, and endodontic infection, suggesting a multifactorial etiology of MRONJ.ConclusionsAlthough this study is based on a small number of cases, it shows that MRONJ is not caused by a specific microorganism but can rather be caused by a variety of factors. By addressing these findings in large-scale studies, the significance of oral microbiome in pathogenesis can be further elucidated and can facilitate the development of effective therapeutic interventions for patients with MRONJ.
Files in This Item:
T202401522.pdf Download
DOI
10.1186/s12903-024-03945-z
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jun-Young(김준영) ORCID logo https://orcid.org/0000-0002-6596-6135
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
Jung, Young Soo(정영수) ORCID logo https://orcid.org/0000-0001-5831-6508
Choi, Yoon Jeong(최윤정) ORCID logo https://orcid.org/0000-0003-0781-8836
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198705
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